Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion
Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion
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DOI：
10.1523/eneuro.0521-21.2022
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发表时间：
2022-06
期刊：
影响因子：
3.4
通讯作者：
Airi Yoshimoto;Yusuke Shibata;Mikuru Kudara;Y. Ikegaya;N. Matsumoto
中科院分区：
文献类型：
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作者：
Airi Yoshimoto;Yusuke Shibata;Mikuru Kudara;Y. Ikegaya;N. Matsumoto
视觉摘要内侧前脑束（MFB）是一条穿过中脑边缘结构的白色物质通路，包括从腹侧被盖区（VTA）上行的多巴胺能神经纤维。由于多巴胺能信号代表享乐反应，在动物中的MFB的电刺激已被用作神经奖励的操作和空间任务。MFB刺激强烈地激励动物快速学习执行各种行为任务以获得奖励。虽然已知MFB连接不同的脑区，并且MFB刺激动态地调节动物行为，但对MFB刺激本身如何影响中枢和外周功能知之甚少。为了解决这个问题，我们同时记录皮层脑电图（ECoGs）在初级运动皮层（M1），初级躯体感觉皮层（S1），和嗅球（OB）的行为大鼠，而电刺激MFB。我们发现，MFB刺激增加大鼠的自发活动。光谱分析证实，MFB刺激后立即，嗅活动促进和M1中的伽马振荡的功率增加。在嗅闻活动和运动皮层伽马振荡被促进后，动物开始移动。这些结果提供了深入了解嗅活动和皮层伽马振荡的重要性，为电机执行和学习促进MFB刺激。
Visual Abstract The medial forebrain bundle (MFB) is a white matter pathway that traverses through mesolimbic structures and includes dopaminergic neural fibers ascending from the ventral tegmental area (VTA). Since dopaminergic signals represent hedonic responses, electrical stimulation of the MFB in animals has been used as a neural reward for operant and spatial tasks. MFB stimulation strongly motivates animals to rapidly learn to perform a variety of behavioral tasks to obtain a reward. Although the MFB is known to connect various brain regions and MFB stimulation dynamically modulates animal behavior, how central and peripheral functions are affected by MFB stimulation per se is poorly understood. To address this question, we simultaneously recorded electrocorticograms (ECoGs) in the primary motor cortex (M1), primary somatosensory cortex (S1), and olfactory bulb (OB) of behaving rats while electrically stimulating the MFB. We found that MFB stimulation increased the locomotor activity of rats. Spectral analysis confirmed that immediately after MFB stimulation, sniffing activity was facilitated and the power of gamma oscillations in the M1 was increased. After sniffing activity and motor cortical gamma oscillations were facilitated, animals started to move. These results provide insight into the importance of sniffing activity and cortical gamma oscillations for motor execution and learning facilitated by MFB stimulation.