GB virus-C – a virus without a disease: We cannot give it chronic fatigue syndrome
GB virus-C – a virus without a disease: We cannot give it chronic fatigue syndrome
复制标题
GB病毒-C——一种没有疾病的病毒：我们不能赋予它慢性疲劳综合症
作者：
James F. Jones;P. Kulkarni;S. Butera;W. Reeves
BackgroundChronic fatigue syndrome (CFS) is an illness in search of an infectious etiology. GB virus-C (GBV-C) virus is a flavivirus with cell tropism and host defense induction qualities compatible with a role in producing the syndrome. The GBV-C genome is detectable in 4% of the population and 12% of the population is seropositive. The present study evaluated the association between infection with GBV and CFS.MethodsWe used a commercial EIA to detect antibodies against the GBV-C E2 protein and a quantitative real-time RT-PCR assay to detect active GBV-C infection. Sera were from a case control study of CFS in Atlanta, Georgia. The Fisher's exact two-tailed test was used for statistical analysis.ResultsTwo of 12 CFS patients and one of 21 controls were seropositive for prior GBV-C infection and one control had viral RNA detected, indicating active infection. The results are not statistically different.ConclusionWe found no evidence that active or past infection with GBV is associated with CFS.
影响因子：
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作者：
Jason, LA;Richman, JA;Plioplys, S
通讯作者：
Plioplys, S