Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice.
Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice.
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简单神经元回路中的随机变异与确定变异：II。
DOI：
10.1016/s0006-3495(94)80527-2
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发表时间：
1994
影响因子：
3.4
通讯作者：
Aitken,PG
中科院分区：
文献类型：
--
作者：
Schiff,SJ;Jerger,K;Chang,T;Sauer,T;Aitken,PG
在大鼠海马片上诱发(驱动)CA1区锥体细胞突触前抽动(放射层)和群峰电位(锥体层)的长时间序列。从正常[K+]灌流的驱动CA1区出发，分析群体峰电位幅度和由群体峰电位幅度除以突触前抽射幅度的输入输出函数。将灌流介质中的[K+]升高至8.5 mm，在CA3诱发脑片自发放电，并记录长时间序列的阵发间期。对这些序列进行了三种决定论测试：局部流动方法的离散适应、局部分散方法和非线性预测。代用数据被生成作为数学和统计控制。正常[K+]驱动电路的所有种群尖峰(6/6)和输入-输出(6/6)时间序列在所有三种方法下都是随机的。尽管来自自主爆发的高[K+]态的大部分时间序列(5/6)未能证明决定论的证据，但这些时间序列中有一(1/6)确实证明了显著的决定论。这种单一的可预测性不能用这些数据中的线性相关性来解释。
Long time series of Schaffer collateral to CA1 pyramidal cell presynaptic volleys (stratum radiatum) and population spikes (stratum pyramidale) were evoked (driven) in rat hippocampal slices. From the driven CA1 region in normal [K+] perfusate, both population spike amplitude and an input-output function consisting of population spike amplitude divided by the presynaptic volley amplitude were analyzed. Raising [K+] in the perfusion medium to 8.5 mM, slices were induced to spontaneously burst fire in CA3 and long time series of inter-burst intervals were recorded. Three tests for determinism were applied to these series: a discrete adaptation of a local flow approach, a local dispersion approach, and nonlinear prediction. Surrogate data were generated to serve as mathematical and statistical controls. All of the population spike (6/6) and input-output (6/6) time series from the normal [K+] driven circuitry were stochastic by all three methods. Although most of the time series (5/6) from the autonomously bursting high [K+] state failed to demonstrate evidence of determinism, one (1/6) of these time series did demonstrate significant determinism. This single instance of predictability could not be accounted for by the linear correlation in these data.