Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.
Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.
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DOI：
10.1186/s40064-016-2794-0
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Komuro I
中科院分区：
文献类型：
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作者：
Amiya E;Watanabe M;Watanabe S;Takata M;Komuro I
本研究的目的是探讨在剪应力增加下动脉脉冲幅度变化与缺血性心脏病（IHD）存在的关系。本研究共纳入31名受试者，其中IHD患者14名。我们利用超声技术研究了血流介导扩张（FMD）过程中肱动脉脉搏幅值的变化。FMD期间动脉脉搏幅值增加19例，减少12例。动脉脉搏幅值（FMD期间动脉脉搏幅值的最大幅值/基线时动脉脉搏幅值）的变化在IHD患者和非IHD患者之间有显著差异（0.98±0.53和1.37±0.53,p = 0.028）。此外，在调整了年龄、血压、各种冠状动脉风险、FMD值和性别后，FMD期间动脉脉冲幅度降低是IHD的重要预测因子（p = 0.0001）。FMD期间动脉搏动幅度的下降是IHD的一个有用的预测参数。本文的在线版本（doi:10.1186/s40064-016-2794-0）包含补充资料，仅供授权用户使用。
The aim of this study is to investigate the relationship between arterial pulse amplitude change under increased shear stress and the presence of ischemic heart disease (IHD). This study comprised 31 subjects, including 14 subjects with IHD. We investigated the change in brachial artery pulse amplitude during flow-mediated dilation (FMD) using ultrasonography. The arterial pulse amplitude increased during FMD in 19 subjects, whereas it decreased in 12 subjects. There was a marked difference in the change in arterial pulse amplitude (the maximum amplitude of the arterial pulse amplitude during FMD/the arterial pulse amplitude at baseline) between subjects with and without IHD (0.98 ± 0.53 and 1.37 ± 0.53, p = 0.028). Furthermore, decreased arterial pulse amplitude during FMD was a significant predictor of IHD after adjustment of age, blood pressure, the presence of each type of coronary risks, the value of FMD and sex (p = 0.0001). The decrease of arterial pulsation amplitude during FMD was a useful predictive parameter for IHD. The online version of this article (doi:10.1186/s40064-016-2794-0) contains supplementary material, which is available to authorized users.