Modulation of Cardiac Fibrosis in and Beyond Cells.
Modulation of Cardiac Fibrosis in and Beyond Cells.
复制标题
细胞内外心脏纤维化的调节
DOI：
10.3389/fmolb.2021.750626
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发表时间：
2021
影响因子：
5
通讯作者：
Kassiri Z
中科院分区：
文献类型：
--
作者：
Fan D;Kassiri Z
细胞外基质（ECM）在维持各种组织和器官的生理结构与功能方面发挥着重要作用。心脏纤维化是指ECM过度沉积，其中包括纤维状（I型和III型胶原蛋白）和非纤维状蛋白质。纤维化的特征会因病理情况而异，局灶性纤维化常见于心肌梗死（MI）之后，而弥漫性间质纤维化和血管周围纤维化主要见于非缺血性心脏病。纤维化组织的顺应性明显低于正常心肌，这可能导致心脏舒张功能障碍以及收缩功能障碍。因此，人们一直在研究对抗心脏纤维化的策略。在受到损伤或发生炎症时，活化的心脏成纤维细胞（肌成纤维细胞）会产生更多的ECM蛋白，从而引发纤维化。通过靶向其特异性表达的蛋白质，可以抑制这种活化过程，或者消融肌成纤维细胞。调节金属蛋白酶组织抑制剂（TIMPs）以及适度运动也能够抑制心脏纤维化。最近，心脏纤维化中的性别差异逐渐受到关注，表现为在心脏病中的纤维化反应不同，以及体外培养的成纤维细胞功能存在差异。这篇小型综述探讨了心脏成纤维细胞、TIMPs、性别差异以及运动在调节心脏纤维化方面的最新研究进展。
The extracellular matrix (ECM) plays important roles in maintaining physiological structure and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of ECM, including both fibrillar (collagens I and III) and non-fibrillar proteins. Characteristics of fibrosis can vary depending on the pathology, with focal fibrosis occurring following myocardial infarction (MI), and diffuse interstitial and perivascular fibrosis mainly in non-ischemic heart diseases. Compliance of the fibrotic tissue is significantly lower than the normal myocardium, and this can compromise the diastolic, as well as systolic dysfunction. Therefore, strategies to combat cardiac fibrosis have been investigated. Upon injury or inflammation, activated cardiac fibroblasts (myofibroblasts) produce more ECM proteins and cause fibrosis. The activation could be inhibited or the myofibroblasts could be ablated by targeting their specific expressed proteins. Modulation of tissue inhibitors of metalloproteinases (TIMPs) and moderate exercise can also suppress cardiac fibrosis. More recently, sex differences in cardiac fibrosis have come to light with differential fibrotic response in heart diseases as well as in fibroblast functions in vitro. This mini-review discusses recent progress in cardiac fibroblasts, TIMPs, sex differences and exercise in modulation of cardiac fibrosis.
DOI：
10.1111/j.1752-8062.2010.00252.x
发表时间：
2011-02
期刊：
Clinical and translational science
影响因子：
--
作者：
Ramani R;Nilles K;Gibson G;Burkhead B;Mathier M;McNamara D;McTiernan CF
通讯作者：
McTiernan CF