Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease
Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease
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DOI：
10.1016/j.jacc.2006.05.054
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发表时间：
2006-09-19
影响因子：
24
通讯作者：
Ogawa, Hisao
中科院分区：
文献类型：
--
作者：
Otsuka, Fumiyuki;Sugiyama, Seigo;Ogawa, Hisao
目的探讨冠心病患者血浆脂联素水平与冠状动脉病变复杂性的关系。背景：糖尿病、代谢综合征等代谢紊乱是急性心血管事件的重要危险因素，脂联素是代谢紊乱的关键分子，具有抗动脉粥样硬化的作用。低血浆脂联素水平与冠心病和未来的心肌梗死发病率相关。脂联素在冠状动脉斑块易损性中的作用尚不清楚。方法我们测定了207名男性(152名稳定的冠心病患者和55名急性冠脉综合征患者)的血浆脂联素水平。结果冠状动脉病变复杂的稳定型患者(n=60)血浆脂联素水平显著低于单纯病变(n=92)(4.14[2.95~6.02]和5.27[3.67~8.12]mU/ml，P=0.006)。多因素Logistic回归分析显示，脂联素水平与复杂病变独立相关(优势比0.514，95%可信区间0.278~0.951；p=0.034)。多因素Logistic回归分析显示，脂联素与单个和多个复杂病变独立相关。在脂联素水平低于稳定型冠状动脉病变的急性冠脉综合征患者中，多个复杂病变者的脂联素水平显著低于单一复杂病变者(3.2 6[2.2 6~4.46]和4.2 1[3.36~5.41]mU g/ml，P=0.032)。脂联素水平低可能是冠状动脉斑块易损性的原因之一。
OBJECTIVES We sought to assess whether plasma adiponectin levels correlate with angiographic coronary lesion complexity in patients with coronary artery disease (CAD).BACKGROUND Metabolic disorders, including diabetes metlitus and metabolic syndrome, are important risk factors for acute cardiovascular events, and adiponectin is a key molecule of metabolic disorders, with anti-atherogenic proper-ties. Low plasma adiponectin levels are associated with CAD and future incidence of myocardial infarction. The involvement of adiponectin in coronary plaque vulnerability, which may be reflected by angiographic complex lesions, remains to be elucidated.METHODS We measured plasma adiponectin levels in 207 men (152 with stable CAD and 55 with acute coronary syndromes [ACS]). Coronary lesions were classified as of simple or complex appearance.RESULTS Plasma adiponectin levels were significantly lower in stable CAI) patients with complex coronary lesions (n = 60) than in those with simple lesions (n = 92) (4.14 [range 2.95 to 6.02] vs. 5.27 [range 3.67 to 8.12] mu g/ml, p = 0.006). Multiple logistic regression analysis demonstrated that adiponectin level was independently associated with complex lesions (odds ratio 0.514, 95% confidence interval 0.278 to 0.951; p = 0.034). Polytomous logistic regression revealed that adiponectin correlated independently with both single and multiple complex lesions. Among patients with ACS, who had lower adiponectin levels than stable CAI) patients, those with multiple complex lesions had significantly lower adiponectin than those with a single complex lesion (3.26 [range 2.26 to 4.46] vs. 4.21 [range 3.36 to 5.41] mu g/ml, p = 0.032).CONCLUSIONS Plasma adiponectin levels are significantly associated with coronary lesion complexity in men with CAD. Low adiponectin levels may contribute to coronary plaque vulnerability.