Ovulation following vaginal stimulation in a spontaneous ovulator and its implications.
Ovulation following vaginal stimulation in a spontaneous ovulator and its implications.
复制标题
自发排卵者阴道刺激后的排卵及其影响。
作者：
M. Zarrow;J. H. Clark
进行了一项研究，以更详细地描述自发排卵时黄体生成素 (LH) 的神经释放，并证明 LH 释放的神经通路存在于周期性自发排卵物种（例如大鼠）中。通过氯丙嗪（CPZ）治疗，孕马血清（PMS）治疗的未成熟大鼠的排卵被阻断。通过 3 个程序诱导反射性排卵并因此诱导 LH 释放：1）将雄性大鼠与经过治疗的雌性大鼠放置过夜，2）用玻璃棒机械刺激阴道和子宫颈，3）电刺激子宫颈。交配或机械刺激分别诱导 77% 和 82% 的大鼠排卵。电刺激效果最差，只有 50% 的人会排卵。发现释放的卵子的平均数量和大鼠排卵的百分比是玻璃棒机械刺激量的函数。盆腔神经切断术消除了反射性排卵反应。性交或机械刺激获得的更强反应表明受体位点可能位于阴道壁。这一假设得到了大鼠阴茎刺的发现的支持。文献调查表明，阴茎刺存在于包括灵长类在内的多种哺乳动物目中。讨论了阴茎棘的存在和反射性排卵的进化关系和影响。有人建议，像老鼠这样的人类以及可能其他自发排卵的物种也有在刺激阴道后排卵的能力。
An investigation was undertaken to describe in greater detail the neural release of luteinizing hormone (LH) in spontaneous ovulation and to demonstrate that a neural pathway of LH release is present in a cyclic spontaneously ovulating species such as the rat. Ovulation was blocked in pregnant mare serum (PMS)-treated immature rats by treatment with chlorpromazine (CPZ). Reflex ovulation and hence LH release was induced by 3 procedures: 1) placing male rats with the treated females overnight 2) mechanical stimulation of the vagina and cervix with a glass rod and 3) electrical stimulation of the uterine cervix. Mating or mechanical stimulation induced ovulation in 77% and 82% of the rats respectively. Electrical stimulation was least effective causing ovulation in only 50%. The average number of ova released and the percentage of rats ovulating was found to be a function of the amount of mechanical stimulation with the glass rod. Pelvic neurotomy abolished the reflex ovulatory response. The stronger response obtained by coitus or mechanical stimuli indicated the possibility of receptor sites in the vaginal wall. This assumption was supported by the finding of penile spines in the rat. A survey of the literature indicates that penile spines are present in a variety of mammalian orders including the primates. The evolutionary relationships and implications of the existence of penile spines and reflex ovulation are discussed. It is suggested that man like the rat and probably other species which ovulate spontaneously also has the ability to ovulated after stimulation of the vaginal tract.