Notch signaling in mammary gland tumorigenesis
Notch signaling in mammary gland tumorigenesis
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DOI：
10.1023/a:1009512414430
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发表时间：
2001-01-01
影响因子：
2.5
通讯作者：
Raafat, A
中科院分区：
文献类型：
--
作者：
Callahan, R;Raafat, A
Notch受体蛋白及其信号通路在整个进化过程中一直很保守，似乎是发育过程中细胞命运决定的关键组成部分。最近的研究表明，根据细胞和发育背景，Notch信号传导也可能影响细胞增殖和程序性细胞死亡。哺乳动物有四个相关的Notch基因。其中之一，命名为Notch-4，被发现是小鼠乳腺肿瘤病毒在小鼠乳腺肿瘤中的常见整合位点。这种类型的病毒整合事件的一个后果是Notch-4细胞内结构域的异位表达，这对应于功能获得性突变。“激活的”Notch-4在乳腺上皮中的表达对乳腺发育和肿瘤发生具有深远的影响。本文就Notch受体的结构、功能以及参与和调节Notch信号通路的成分进行综述。最后讨论了Notch在乳腺发育和肿瘤发生中的潜在作用。
The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and programmed cell death. Mammals have four related Notch genes. One of these, designated Notch-4, was found to be a common integration site for the mouse mammary tumor virus in mouse mammary tumors. One consequence of this type of viral integration event is the ectopic expression of the intracellular domain of Notch-4 that corresponds to a gain-of-function mutation. Expression of "activated" Notch-4 in mammary epithelium has profound effects on mammary gland development and tumorigenesis. In this review, we briefly summarize the structure and function of the Notch receptor, as well as the components that comprise and modify the signaling pathway. Finally we discuss the potential role of Notch in mammary gland development and tumorigenesis.