Postnatal Action of Growth and Thyroid Hormones on the Retarded Cerebral Myelinogenesis of Snell Dwarf Mice (dw)
Postnatal Action of Growth and Thyroid Hormones on the Retarded Cerebral Myelinogenesis of Snell Dwarf Mice (dw)
复制标题
生长激素和甲状腺激素对斯内尔侏儒小鼠脑髓鞘形成迟缓的出生后作用 (dw)
作者：
T. Noguchi;T. Sugisaki;Y. Tsukada
摘要：Snell侏儒小鼠（dw）仅在CNS不同部位的大脑中显示出较低的CNE2活性（正常对照的59%），并且在40日龄的24 h记录中，自发运动活动水平显著降低，昼夜周期不明显。在出生后的前40天内，每天给侏儒服用bGH和T4，使CNR活性恢复到正常对照组的水平，并伴随着自发运动活动模式的正常化。每天单独给予bGH也恢复了CNE2活性和自发运动，但程度较低。然而，每天单独给予促甲状腺激素（TSH）未能恢复CNR活性，尽管TSH治疗的侏儒的甲状腺在组织和外观上与正常对照组没有区别。这些结果表明，恢复延迟的髓鞘形成和异常行为的Snell侏儒小鼠可能主要取决于GH水平和T4的协同作用。
Abstract: Snell dwarf mice (dw) showed a lower CNPase activity (59% of the normal controls) only in the cerebrum among different parts of the CNS, and a strikingly reduced level of spontaneous locomotion activity with an indistinct diurnal periodicity in a 24‐h record at 40 days of age. Daily administration of bGH and T4 to the dwarfs during the first 40 days of postnatal life restored CNPase activity to the level of the normal controls, and was accompanied by normalization of the pattern of spontaneous locomotion activity. Daily administration of bGH alone also restored CNPase activity and spontaneous locomotion, but to a lesser extent. The daily administration of thyroid stimulating hormone (TSH) alone, however, failed to restore CNPase activity, in spite of the fact that the thyroid glands of the TSH‐treated dwarfs were indistinguishable from the normal controls in organization and appearance. These results indicate that the restoration of both the retarded myelinogenesis and abnormal behavior of the Snell dwarf mice might essentially depend upon GH levels and the synergistic effects of T4.