Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum
Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum
复制标题
DOI：
10.1016/s0031-9422(01)00174-1
复制
发表时间：
2001-08-01
期刊：
影响因子：
3.8
通讯作者：
Sticher, O
中科院分区：
文献类型：
--
作者：
Heilmann, J;Brun, R;Sticher, O
从白豆蔻（Amomum aculeatum）根茎中分离得到一种新的具有细胞毒性的1，7-二氧杂-二螺[5.1.5.2]十五碳-9，2-二烯-11-酮衍生物，即白豆蔻素D（aculeatin D）和一种新的烯酮，即5-羟基-二十六碳-1-烯-3-酮。它们的结构主要通过NMR光谱和质谱确定。Aculeatin D对KB和L-6细胞系显示出高细胞毒性，IC 50分别为0.38 μ g/ml和1 μ g/ml。此外，它还显示出对两种恶性疟原虫菌株以及布氏锥虫和克氏锥虫的显著活性。5-羟基-二十六碳-1-烯-3-酮既没有细胞毒性也没有抗原虫活性，而对蜡状芽孢杆菌、大肠杆菌和表皮葡萄球菌的抗菌试验表明，两种化合物都具有中等至较强的活性。(C)2001由Elsevier Science Ltd.出版。保留所有权利。
A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,2-dien-11-one derivative, aculeatin D, and a new alkenone, 5-hydroxy-hexacos-1-en-3-one, have been isolated as minor compounds from the rhizomes of Amomum aculeatum. Their structures have been determined mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 mug/ml and 1 mug/ml, respectively. Additionally, it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compounds. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.