BLAST: at the core of a powerful and diverse set of sequence analysis tools
BLAST: at the core of a powerful and diverse set of sequence analysis tools
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DOI：
10.1093/nar/gkh435
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发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Madden, TL
中科院分区：
文献类型：
--
作者：
McGinnis, S;Madden, TL
基本局部比对搜索工具（Basic Local Alignment Search Tool，BLAST）是公共领域中最常用的序列分析工具之一。现在有多种BLAST算法可供选择，其可用于通过BLAST网页（http：//www.ncbi.nlm.nih.gov/BLAST/）搜索许多不同的序列数据库。所有算法-数据库组合都可以使用默认参数或自定义设置执行，并且可以以各种方式查看结果。一个新的在线资源，BLAST程序选择指南，已经创建，以帮助定义的搜索策略。本文讨论了最佳搜索策略，并强调了一些可以使搜索更强大的BLAST功能。
Basic Local Alignment Search Tool (BLAST) is one of the most heavily used sequence analysis tools available in the public domain. There is now a wide choice of BLAST algorithms that can be used to search many different sequence databases via the BLAST web pages (http://www.ncbi.nlm.nih.gov/BLAST/). All the algorithm-database combinations can be executed with default parameters or with customized settings, and the results can be viewed in a variety of ways. A new online resource, the BLAST Program Selection Guide, has been created to assist in the definition of search strategies. This article discusses optimal search strategies and highlights some BLAST features that can make your searches more powerful.