LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13
LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13
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DOI：
10.1126/science.8091231
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发表时间：
1994-09-30
期刊：
影响因子：
56.9
通讯作者：
STRATTON, MR
中科院分区：
文献类型：
--
作者：
WOOSTER, R;NEUHAUSEN, SL;STRATTON, MR
一小部分乳腺癌，特别是年轻时发生的乳腺癌，是由于显性易感基因的遗传导致该疾病的高风险。对 15 个与染色体 17q21 上的 BRCA1 基因座无关的高风险乳腺癌家族进行了基因组连锁搜索。该分析将第二个乳腺癌易感位点 BRCA2 定位于染色体 13q12-13 上 6 厘摩间隔。初步证据表明，BRCA2 会增加患乳腺癌的风险，但与 BRCA1 不同的是，BRCA2 不会大幅增加患卵巢癌的风险。
A small proportion oi breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.