Control of macrophage activation and function by PPARs.
Control of macrophage activation and function by PPARs.
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DOI：
10.1161/circresaha.110.216523
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发表时间：
2010-05-28
影响因子：
20.1
通讯作者：
Chawla A
中科院分区：
文献类型：
--
作者：
Chawla A
巨噬细胞是抵抗病原体的先天防御的关键组成部分，参与炎症的启动和消退以及组织的维持。巨噬细胞的这些不同的和有时对立的功能通过不同的激活状态执行，从经典到替代到失活。由于巨噬细胞活化的失调在病理上与各种代谢、炎症和免疫病症相关，因此控制巨噬细胞活化的调节蛋白已成为重要的新治疗靶标。在这里，过氧化物酶体激活受体（PPARs）转录调节巨噬细胞激活的健康和疾病状态，包括肥胖，胰岛素抵抗和心血管疾病的机制，将进行审查。
Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to alternative to deactivation. Because the dysregulation of macrophage activation is pathogenically linked to various metabolic, inflammatory and immune disorders, regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets. Here, the mechanisms by which Peroxisome Proliferator Activated Receptors (PPARs) transcriptionally regulate macrophage activation in health and disease states, including obesity, insulin resistance and cardiovascular disease, will be reviewed.