P50 SUPPRESSION IS NOT AFFECTED BY ATTENTIONAL MANIPULATIONS
P50 SUPPRESSION IS NOT AFFECTED BY ATTENTIONAL MANIPULATIONS
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DOI：
10.1016/0006-3223(92)90230-w
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发表时间：
1992-02-15
影响因子：
10.6
通讯作者：
FEIN, G
中科院分区：
文献类型：
--
作者：
JERGER, K;BIGGINS, C;FEIN, G
记录正常青壮年受试者的中高强度听觉诱发电位(EP)，单次或成对短声。选择-反应-时间范式有两套指令，分别用于强度辨别和数字辨别(单刺激与成对刺激)。对于强度辨别，第二次短声没有信息量，其N100波幅较第一次明显降低。对于数字辨别，第二次点击的有无提供了显著的信息，第二次点击的N100波幅实际上比第一次点击的幅度略大。相反，注意操作对P50波幅没有影响，从第一次点击到第二次点击，两项任务的P50波幅都有50%以上的抑制。因此，对一对短声的第二个P50波幅的抑制对对N100波幅有重大影响的注意操作不敏感。这些发现表明，精神分裂症患者P50抑制的异常反映了神经元现象，而不是心理现象。
Auditory evoked potentials (EP) to high or moderate intensity, single or paired clicks were recorded from normal young adult subjects. A choice-reaction-time paradigm had two sets of instructions, for intensity discrimination and for number (single versus paired stimulus) discrimination. For intensity discrimination, the second click had no informative value and its N100 amplitude was markedly reduced relative to the first click. For number discrimination, the presence or absence of the second click provided the salient information, and N100 amplitude was actually slightly larger for the second compared to the first click. In contrast, the attentional manipulation had no effect on P50 amplitude, which showed over 50% suppression from the first to the second click for both tasks. Thus, suppression of P50 amplitude to the second of a pair of clicks is insensitive to attentional manipulations that have major effects on N100 amplitude. These findings suggest that abnormalities of schizophrenic P50 suppression reflect neuronal rather than psychological phenomena.