CONCENTRATION OF INDOOR PARTICULATE MATTER AS A DETERMINANT OF RESPIRATORY HEALTH IN CHILDREN
CONCENTRATION OF INDOOR PARTICULATE MATTER AS A DETERMINANT OF RESPIRATORY HEALTH IN CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a116952
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发表时间：
1994-06-01
影响因子：
5
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
--
作者：
NEAS, LM;DOCKERY, DW;SPEIZER, FE
1983-1988年，对美国6个城市7-11岁白人儿童进行了被动暴露于室内环境烟草烟雾对呼吸道症状和肺功能水平的影响的研究。对于2994名有基于问卷调查的暴露数据的儿童来说，被动暴露于每天在家里吸烟的额外一包香烟与下呼吸道症状的发生率增加相关(优势比(OR)=1.25，95%可信区间(CI)1.10-1.42)。对于1237名在冬季和夏季连续两次测量1周的儿童来说，室内空气动力学直径为2.5微米(PM(2.5))的可吸入颗粒物年平均浓度增加30微克/立方米(3)--即大约相当于每天一包烟的影响--与下呼吸道症状累积发生率的增加略有关联(OR=1.13，95%CI 0.99-1.30)。室内测量的PM(2.5)与儿童的肺功能测量没有直接联系。母亲在怀孕期间吸烟的儿童经容量调整后的用力呼气流速降低了2.6%(95%可信区间-5.2%至0.1%)。因此，目前室内暴露于PM(2.5)会增加下呼吸道症状的累积发生率，但与青春期前儿童肺功能水平下降的相关性很小。
The effect of passive exposure to environmental tobacco smoke in the home on respiratory symptoms and pulmonary function level was studied in a cohort of white children aged 7-11 years examined in six US cities in 1983-1988. For 2,994 children with questionnaire-based exposure data, passive exposure to an additional pack of cigarettes smoked daily in the home was associated with increased incidence of lower respiratory symptoms (odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.10-1.42). For 1,237 children with two consecutive 1-week measurements in both winter and summer, a 30-mu g/m(3) increase in the annual average indoor concentration of respirable particulate matter with an aerodynamic diameter of < 2.5 mu m (PM(2.5))-that is, approximately the effect of one pack per day of smoking-was marginally associated with an increased cumulative incidence of lower respiratory symptoms (OR = 1.13, 95% CI 0.99-1.30). Indoor measurements of PM(2.5) showed no direct association with children's pulmonary function measurements. Children whose mothers smoked during pregnancy showed a reduction of -2.6% (95% CI -5.2% to 0.1%) in volume-adjusted forced expiratory flow rates. Therefore, current indoor exposure to PM(2.5) increases the cumulative incidence of lower respiratory symptoms, but is only weakly associated with decreased pulmonary function level in preadolescent children.