Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.
Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.
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DOI：
10.1682/jrrd.2014.10.0267
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发表时间：
2016
影响因子：
--
通讯作者：
Rasmusson AM
中科院分区：
文献类型：
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作者：
Scioli-Salter E;Forman DE;Otis JD;Tun C;Allsup K;Marx CE;Hauger RL;Shipherd JC;Higgins D;Tyzik A;Rasmusson AM
这项初步研究评估了心肺运动试验和心肺功能对血浆神经肽Y（NPY），别孕烯醇酮和孕烯醇酮（ALLO），皮质醇和脱氢表雄酮（DHEA）的影响，以及它们与疼痛敏感性的关系。无药物创伤暴露的参与者是健康的（n = 7）或患有慢性疼痛/创伤后应激障碍（PTSD）（n = 5）。运动试验期间的峰值耗氧量（VO 2）用于表征心肺适应性。峰值VO 2与基线和峰值NPY水平相关（分别为r = 0.66，p < 0.05和r = 0.69，p < 0.05），以及运动诱导的ALLO变化（r = 0.89，p < 0.001）和ALLO峰值水平（r = 0.71，p < 0.01）。运动峰值时的NPY水平与运动后30 min的痛阈相关（r = 0.65，p < 0.05），而运动诱导的ALLO增加与运动后30 min的疼痛耐受性相关（r = 0.64，p < 0.05）。相反，运动引起的皮质醇和DHEA水平的变化与运动后的疼痛耐受性呈负相关（分别为r =-0.69，p < 0.05和r =-0.58，p < 0.05）。这些数据表明，心肺功能与较高的血浆NPY水平和对运动的ALLO反应增加有关，这反过来又与疼痛敏感性有关。未来的工作将研究渐进式运动训练是否会增加与慢性疼痛PTSD患者的NPY和ALLO增加以及疼痛敏感性降低相关的心肺功能。
This pilot study assessed the effects of cardiopulmonary exercise testing and cardiorespiratory fitness on plasma neuropeptide Y (NPY), allopregnanolone and pregnanolone (ALLO), cortisol, and dehydroepiandrosterone (DHEA), and their association with pain sensitivity. Medication-free trauma-exposed participants were either healthy (n = 7) or experiencing comorbid chronic pain/posttraumatic stress disorder (PTSD) (n = 5). Peak oxygen consumption (VO2) during exercise testing was used to characterize cardiorespiratory fitness. Peak VO2 correlated with baseline and peak NPY levels (r = 0.66, p < 0.05 and r = 0.69, p < 0.05, respectively), as well as exercise-induced changes in ALLO (r = 0.89, p < 0.001) and peak ALLO levels (r = 0.71, p < 0.01). NPY levels at the peak of exercise correlated with pain threshold 30 min after exercise (r = 0.65, p < 0.05), while exercise-induced increases in ALLO correlated with pain tolerance 30 min after exercise (r = 0.64, p < 0.05). In contrast, exercise-induced changes in cortisol and DHEA levels were inversely correlated with pain tolerance after exercise (r = −0.69, p < 0.05 and r = −0.58, p < 0.05, respectively). These data suggest that cardiorespiratory fitness is associated with higher plasma NPY levels and increased ALLO responses to exercise, which in turn relate to pain sensitivity. Future work will examine whether progressive exercise training increases cardiorespiratory fitness in association with increases in NPY and ALLO and reductions in pain sensitivity in chronic pain patients with PTSD.