The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.
The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.
复制标题
前边缘-下边缘区域多巴胺 D(1) 受体阻断对行为灵活性的影响。
DOI：
10.1101/lm.45802
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Ragozzino,MichaelE
中科院分区：
文献类型：
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作者：
Ragozzino,MichaelE
本研究探讨了多巴胺D1受体拮抗剂，SCH 23390，注入到前边缘-边缘下区的收购的反应和视觉线索的歧视任务，以及从一个响应到视觉线索的歧视，反之亦然的转变。每个测试在十字迷宫中进行。反应辨别需要学习总是转向同一个方向（右或左）以获得谷物强化。视觉线索辨别需要学习总是进入视觉线索的手臂。在实验1中，大鼠被测试的反应辨别任务，然后由视觉线索辨别任务。在实验2中，测试顺序颠倒。将SCH 23390（0.1或1 μg/0.5 μL）双侧注入边缘前-边缘下区不会损害反应或视觉线索辨别任务的获得。注射1 μg而非0.1 μg的SCH 23390会在从反应转换为视觉线索辨别时损害表现，反之亦然。对错误的分析表明，这种缺陷是由于对先前学习的策略的坚持。这些结果表明，多巴胺D1受体的激活在边缘前区，边缘下区可能是至关重要的抑制以前的相关策略和/或产生新的策略。
This study examined the effects of a dopamine D1antagonist, SCH23390, infused into the prelimbic–infralimbic areas on the acquisition of a response and visual-cue discrimination task, as well as a shift from a response to a visual-cue discrimination and vice versa. Each test was carried out in a cross-maze. The response discrimination required learning to always turn in the same direction (right or left) for a cereal reinforcement. The visual-cue discrimination required learning to always enter the arm with the visual cue. In experiment 1, rats were tested on the response discrimination task, followed by the visual-cue discrimination task. In experiment 2, the testing order was reversed. Bilateral infusions of SCH23390 (0.1 or 1 μg/0.5 μL) into the prelimbic–infralimbic areas did not impair acquisition of the response or visual-cue discrimination tasks. SCH23390 injections at 1 μg, but not 0.1 μg impaired performance when shifting from a response to a visual-cue discrimination, and vice versa. Analysis of the errors revealed that the deficit was due to perseveration of the previously learned strategy. These results suggest that activation of dopamine D1receptors in the prelimbic–infralimbic areas may be critical for the suppression of a previously relevant strategy and/or generating new strategies.