Neonatal neurobehavioral and neuroanatomic correlates of prenatal cocaine exposure - Problems of dose and confounding
Neonatal neurobehavioral and neuroanatomic correlates of prenatal cocaine exposure - Problems of dose and confounding
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DOI：
10.1111/j.1749-6632.1998.tb09725.x
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发表时间：
1998-01-01
期刊：
影响因子：
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通讯作者：
Zuckerman, BS
中科院分区：
文献类型：
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作者：
Frank, DA;Augustyn, M;Zuckerman, BS
研究人员在研究产前可卡因暴露对婴儿结局的影响时，面临着复杂的方法学挑战。其中包括在确定妊娠时间和胎儿暴露的可卡因剂量方面不可避免的不精确，以及在识别和量化混杂、中介和调节变量方面的困难。回顾研究新生儿行为和颅超声结果后，在子宫内可卡因暴露是用来说明这些问题。我们的结论是，产前可卡因暴露对婴儿中枢神经系统的结构和功能有可测量的但不是显著的剂量相关影响。产前可卡因暴露剂量对儿童后期发育的影响仍有待确定。若能在科学上达成共识，界定出产前可卡因接触的相对剂量，将有助于这类研究。
Complex methodologic challenges face researchers studying the effects of prenatal cocaine exposure on infant outcome. These include unavoidable imprecision in ascertaining the gestational timing and dose of cocaine to which the fetus was exposed and difficulties in identifying and quantifying the confounding, mediating, and moderating variables. Review of research on neonatal behavioral and cranial ultrasound findings following in utero cocaine exposure is used to illustrate these issues. We conclude that there are measurable but not dramatic dose-related effects of prenatal cocaine exposure on infant central nervous system structure and function. The effects of dose of prenatal cocaine exposure on later child development remain to be determined. Such research would be facilitated by a scientific consensus delineating relative doses of prenatal cocaine exposure.