Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.
Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.
复制标题
铬调节细胞胆固醇稳态和因高胰岛素血症而受损的 ABCA1 功能的证据 - 简要报告。
DOI：
10.1161/atvbaha.110.222158
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Elmendorf,JeffreyS
中科院分区：
文献类型：
--
作者：
Sealls,Whitney;Penque,BrentA;Elmendorf,JeffreyS
ObjectiveTrivalent chromium (Cr3+) is an essential micronutrient. Findings since the 1950s suggest that Cr3+might benefit cholesterol homeostasis. Here we present mechanistic evidence in support of this role of Cr3+.Methods and ResultsHigh-density lipoprotein cholesterol generation in 3T3-L1 adipocytes, which are rendered ineffective by the hyperinsulinemia that is known to accompany disorders of lipid metabolism, was corrected by Cr3+. Mechanistically, Cr3+reversed hyperinsulinemia-induced cellular cholesterol accrual and associated defects in cholesterol transporter ATP-binding cassette transporter-A1 trafficking and apolipoprotein A1–mediated cholesterol efflux. Moreover, direct activation of AMP-activated protein kinase, which is known to be activated by Cr3+, or inhibition of hexosamine biosynthesis pathway activity, which is known to be elevated by hyperinsulinemia, mimics Cr3+action.ConclusionThese findings suggest a mechanism of Cr3+action that fits with long-standing claims of its role in cholesterol homeostasis. Furthermore, these data imply a mechanistic basis for the coexistence of dyslipidemia with hyperinsulinemia.
