Three-dimensional MR Fingerprinting for Quantitative Breast Imaging
Three-dimensional MR Fingerprinting for Quantitative Breast Imaging
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DOI：
10.1148/radiol.2018180836
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发表时间：
2019-01-01
期刊：
影响因子：
19.7
通讯作者：
Gulani, Vikas
中科院分区：
文献类型：
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作者：
Chen, Yong;Panda, Ananya;Gulani, Vikas
目的：建立一种快速三维同时定量乳腺磁共振指纹成像T1和T2的方法。材料和方法：在这项前瞻性研究中，采用可变翻转角度和磁化制备模块来获取三维数据集的每个分区的MR指纹数据。利用奇异值分解实现了一种快速后处理方法。该技术首先在幻影中进行验证，然后在2016年3月至2018年4月期间将其应用于15名健康女性参与者（平均年龄24.2岁+/- 5.1标准差），范围为18-35岁)和14名乳腺癌女性参与者（平均年龄55.4岁+/- 8.8岁，范围为39-66岁）。采用Bloch-Siegert法评价了该方法对B-1场不均匀性的敏感性。结果：幻影结果显示，采用所提出的技术可以实现准确和体积的T1和T2定量。空间分辨率为1.6 x 1.6 x 3mm(3)的三维定量地图采集时间约为6分钟。对于健康参与者，3.0 T时纤维腺组织的T1和T2平均松弛时间分别为1256 msec +/- 171和46 msec +/- 7。浸润性导管癌的T2松弛时间较正常乳腺组织高（68 msec +/- 13） （P < 0.001）， T1松弛时间较正常乳腺组织高（1183 msec +/- 256, P = 0.37）。结论：建立了一种利用MR指纹技术进行乳腺成像的方法，该方法可以同时和体积量化乳腺组织的T1和T2松弛时间。(c) RSNA， 2018年
Purpose: To develop a fast three-dimensional method for simultaneous T1 and T2 quantification for breast imaging by using MR fingerprinting.Materials and Methods: In this prospective study, variable flip angles and magnetization preparation modules were applied to acquire MR fingerprinting data for each partition of a three-dimensional data set. A fast postprocessing method was implemented by using singular value decomposition. The proposed technique was first validated in phantoms and then applied to 15 healthy female participants (mean age, 24.2 years +/- 5.1 standard deviation]; range, 18-35 years) and 14 female participants with breast cancer (mean age, 55.4 years +/- 8.8; range, 39-66 years) between March 2016 and April 2018. The sensitivity of the method to B-1 field inhomogeneity was also evaluated by using the Bloch-Siegert method.Results: Phantom results showed that accurate and volumetric T1 and T2 quantification was achieved by using the proposed technique. The acquisition time for three-dimensional quantitative maps with a spatial resolution of 1.6 x 1.6 x 3 mm(3) was approximately 6 minutes. For healthy participants, averaged T1 and T2 relaxation times for fibroglandular tissues at 3.0 T were 1256 msec +/- 171 and 46 msec +/- 7, respectively. Compared with normal breast tissues, higher T2 relaxation time (68 msec +/- 13) was observed in invasive ductal carcinoma (P < .001), whereas no statistical difference was found in T1 relaxation time (1183 msec +/- 256; P = .37).Conclusion: A method was developed for breast imaging by using the MR fingerprinting technique, which allows simultaneous and volumetric quantification of T1 and T2 relaxation times for breast tissues. (c) RSNA, 2018