High screening blood pressure is related to sympathetic nervous system activity and insulin resistance in healthy young men
High screening blood pressure is related to sympathetic nervous system activity and insulin resistance in healthy young men
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DOI：
10.1080/08037050310031008
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发表时间：
2004-04-01
期刊：
影响因子：
1.8
通讯作者：
Kjeldsen, S
中科院分区：
文献类型：
--
作者：
Fossum, E;Hoieggen, A;Kjeldsen, S
心血管代谢综合征的特征是存在多种心血管危险因素，包括血压升高。本研究旨在探讨不同血压筛查水平的健康高加索青年男性心理应激、血浆儿茶酚胺、血压及血压反应之间的关系。我们包括98名男性高血压患者和22名血压正常的男性患者。他们在实验室中进行基线检查，在高胰岛素、等血糖的葡萄糖钳夹期间和精神应激期间进行检查。在实验室基线时，与血压正常的男性相比，高筛查血压的男性的特征是血压(p<；0.005)和血浆儿茶酚胺(p<；0.05)升高，但血脂水平没有改变。休息2小时后，这些差异几乎消失，但在心算压力测试中可以重现。筛查血压升高的男性空腹血糖显著升高(p=0.005)，胰岛素敏感性显著降低(p<；在多元回归模型中，精神应激期间的去甲肾上腺素(R-2=0.10，p<；0.05)是回溯地解释分配到正常或高筛查BP组的主要变量。总而言之，筛查血压升高的年轻健康男性的特征是交感神经活性增加和胰岛素抵抗。精神应激期间的去甲肾上腺素是解释血压正常或升高组分配的主要变量。我们已经证明，在这个队列中，一次筛查血压测量可以预测胰岛素抵抗和空腹血糖升高。
The cardiovascular metabolic syndrome is characterized by the presence of several cardiovascular risk factors, including blood pressure (BP) elevation. We aimed to study the relation between mental stress, plasma catecholamines, BP and BP responses to mental stress in healthy young Caucasian men selected from different levels of screening BP. We included 98 men with high and 22 men with normal screening BP. They were examined at baseline in the laboratory, during a hyperinsulinemic, isoglycemic glucose clamp and during mental stress. At baseline in the laboratory, the men with high screening BP were characterized by elevated BP ( p < 0.005) and plasma catecholamines ( p < 0.05), but unaltered serum lipid levels compared to men with normal screening BP. After 2 h rest the differences almost disappeared, but could be reproduced during a mental arithmetic stress test. The men with elevated screening BP had significantly higher fasting glucose ( p = 0.01) and lower insulin sensitivity ( p < 0.005). In a multiple regression model, norepinephrine during mental stress (R-2 = 0.10, p < 0.05) was the main variable to retrospectively explain allocation to the normal or high screening BP group. In conclusion, young healthy men with elevated screening BP are characterized by increased sympathetic activity and insulin resistance. Norepinephrine during mental stress is the main variable to explain allocation to the normal or elevated screening BP group. We have shown that one single screening BP measurement predicts insulin resistance and elevated fasting glucose in this cohort.