Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses.
Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses.
复制标题
新型免疫调节途径及其在患有侵袭性真菌病的器官移植受者的免疫重建综合征中的作用。
DOI：
10.1007/s10096-008-0461-2
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Singh,N
中科院分区：
文献类型：
--
作者：
Singh,N
Immune regulatory pathways involving the newly discovered T regulatory (Treg) and Th17 cells are amongst the principal targets of immunosuppressive agents employed in transplant recipients and key mediators of host inflammatory responses in fungal infections. These novel signaling pathways, in concert with or independent of Th1/Th2 responses, have potentially important implications for yielding valuable insights into the pathogenesis of immune reconstitution syndrome (IRS) in transplant recipients, for aiding the diagnosis of this entity, and for achieving a balance of immune responses that enhance host immunity while curbing unfettered inflammation in IRS.
