A new neonatal cortical and subcortical brain atlas: the Melbourne Children's Regional Infant Brain (M-CRIB) atlas
A new neonatal cortical and subcortical brain atlas: the Melbourne Children's Regional Infant Brain (M-CRIB) atlas
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DOI：
10.1016/j.neuroimage.2016.09.068
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发表时间：
2017-02-15
期刊：
影响因子：
5.7
通讯作者：
Thompson, Deanne K.
中科院分区：
文献类型：
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作者：
Alexander, Bonnie;Murray, Andrea L.;Thompson, Deanne K.
调查新生儿大脑结构和功能可以为健康和临床人群的行为和认知提供有价值的见解；无论是在足月年龄，还是在纵向上与之后的时间点相比。成人群体的脑图谱很容易获得，但是由于这些群体之间的形态和组织差异，将婴儿数据翘曲到成人模板空间并不理想。已经开发了几个包裹的新生儿地图集，尽管仍然强烈需要手动包裹的具有详细皮层定义的地面真实数据。此外，与现有成人地图集的兼容性有利于纵向调查的使用。我们的目标是通过在新生儿中复制广泛使用的Desikan-Killiany（2006）成人皮质图谱来解决这些需求。我们还旨在通过基底节区、丘脑、小脑和其他皮质下分割补充这种皮质方案来扩大大脑覆盖范围。因此，我们使用高分辨率新生儿t -2加权MRI扫描对这些区域进行了手动分割，并进行了初始的自动和手动编辑的组织分类，总共提供了100个区域。生成了线性和非线性t -2加权结构模板。在本文中，我们提供了手动分组方案，并将分组概率图和结构模板一起作为墨尔本儿童区域婴儿脑（M-CRIB）图谱。
Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T-2-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T-2-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.