Microvascular anomaly conditions in psychiatric disease. Schizophrenia - angiogenesis connection.
Microvascular anomaly conditions in psychiatric disease. Schizophrenia - angiogenesis connection.
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DOI：
10.1016/j.neubiorev.2017.04.003
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发表时间：
2017-06
影响因子：
8.2
通讯作者：
Haroutunian V
中科院分区：
文献类型：
--
作者：
Katsel P;Roussos P;Pletnikov M;Haroutunian V
精神分裂症(SZ)是一种病因不明、神经病理和神经生物学特征难以捉摸的严重精神障碍，一直是许多理论假设和实证研究的焦点。目前与SZ相关的遗传和神经生物学信息涉及神经元发育和突触可塑性异常，以及神经递质、小胶质细胞和少突胶质细胞功能障碍。最近的几种理论强调神经血管单位是SZ病理生理学的潜在贡献者。我们通过检查遗传、神经成像和尸检获得的洞察力，包括基因表达和神经病理学分析，探索了SZ和神经血管系统之间联系的生物学合理性。我们还综述了脑血管生成动物模型的信息，以更好地了解血管生成因子和神经营养因子在发育、血管内皮细胞/血脑屏障重构和维持中的复杂相互作用，所有这些都有助于维持充足的局部血流和保护正常的脑功能。SZ的微血管和血流动力学改变突出了进一步研究的重要性，并揭示了神经血管单位作为SZ潜在的治疗靶点。
Schizophrenia (SZ) is a severe mental disorder with unknown etiology and elusive neuropathological and neurobiological features have been a focus of many theoretical hypotheses and empirical studies. Current genetic and neurobiology information relevant to SZ implicates neuronal developmental and synaptic plasticity abnormalities, and neurotransmitter, microglial and oligodendrocytes dysfunction. Several recent theories have highlighted the neurovascular unit as a potential contributor to the pathophysiology of SZ. We explored the biological plausibility of a link between SZ and the neurovascular system by examining insights gained from genetic, neuroimaging and postmortem studies, which include gene expression and neuropathology analyses. We also reviewed information from animal models of cerebral angiogenesis in order to understand better the complex interplay between angiogenic and neurotrophic factors in development, vascular endothelium/blood brain barrier remodeling and maintenance, all of which contribute to sustaining adequate regional blood flow and safeguarding normal brain function. Microvascular and hemodynamics alterations in SZ highlight the importance of further research and reveal the neurovascular unit as a potential therapeutic target in SZ.