White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women - Atherosclerosis risk in communities study
White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women - Atherosclerosis risk in communities study
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DOI：
10.1093/aje/154.8.758
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发表时间：
2001-10-15
影响因子：
5
通讯作者：
Wolfe, DA
中科院分区：
文献类型：
--
作者：
Lee, CD;Folsom, AR;Wolfe, DA
作者研究了白色血细胞（WBC）计数与冠心病和缺血性中风的发病率以及心血管疾病死亡率之间的关系，研究对象为来自社区动脉粥样硬化风险（ARIC）研究的13,555名非洲裔美国人和白色男性和女性。从1987-1989年开始，在ARIC基线检查时抽血。在平均8年的随访期间（至1996年12月），有488例冠心病事件，220例中风事件和258例心血管疾病死亡。校正年龄、性别、ARIC中心和多种危险因素后，在非裔美国人中，WBC计数与冠心病（趋势p < 0.001）和中风（趋势p < 0.001）的发病率和心血管疾病死亡率（趋势p < 0.001）之间存在直接相关性。白细胞计数最高四分位数的非裔美国人（大于或等于7,000个细胞/毫米（3））有1.9倍的风险发生冠心病（95%置信区间（CI）：1.19，3.09），缺血性卒中发生风险的1.9倍（95% CI：1.03，3.34），心血管疾病死亡风险是WBC计数最低四分位数（
The authors examined the association between white blood cell (WBC) count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in 13,555 African-American and White men and women from the Atherosclerosis Risk in Communities (ARIC) Study. Blood was drawn at the ARIC baseline examination, beginning in 1987-1989. During an average of 8 years of follow-up (through December 1996), there were 488 incident coronary heart disease events, 220 incident strokes, and 258 deaths from cardiovascular disease. After adjustment for age, sex, ARIC field center, and multiple risk factors, there was a direct association between WBC count and incidence of coronary heart disease (p < 0.001 for trend) and stroke (p for trend < 0.001) and mortality from cardiovascular disease (p for trend < 0.001) in African Americans. The African Americans in the highest quartile of WBC count (greater than or equal to7,000 cellS/mm(3)) had 1.9 times the risk of incident coronary heart disease (95% confidence interval (CI): 1.19, 3.09), 1.9 times the risk of incident ischemic stroke (95% CI: 1.03, 3.34), and 2.3 times the risk of cardiovascular disease mortality (95% CI: 1.38, 3.72) as their counterparts in the lowest quartile of WBC count (