Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: Biomechanical implications
Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: Biomechanical implications
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DOI：
10.1359/jbmr.2000.15.10.1981
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发表时间：
2000-10-01
影响因子：
6.2
通讯作者：
Lane, NE
中科院分区：
文献类型：
--
作者：
Kinney, JH;Haupt, DL;Lane, NE
本文总结了卵巢切除（OVX）后120天L6大鼠椎体形态变化的三维研究结果，以雌激素替代治疗为阳性对照，使用同步辐射微断层扫描来量化定义小梁骨结构的结构参数，同时使用有限元方法来探索这些参数与椎骨压缩弹性行为之间的关系。OVX术后小梁骨体积（TBV）减少22%，平均小梁厚度（Tb.Th）减少19%，小梁连通性增加150%，这是小梁钢板穿孔的结果。从皮质壳中取出的小梁骨的有限元分析显示，OVX后压缩杨氏模量下降37%，而雌激素治疗组没有明显变化，完整的椎骨（包括其小梁骨）显示OVX后模量下降15%，但这种下降缺乏统计学意义，OVX引起的小梁结构变化与在胫骨近端观察到的变化不同。这种差异是椎骨小梁更像板状结构的结果。
This article summarizes the results of a three-dimensional study of changes in the morphology of the L6 rat vertebra at 120 days after ovariectomy (OVX), with estrogen replacement therapy used as a positive control, Synchrotron radiation microtomography was used to quantify the structural parameters defining trabecular bone architecture, while finite-element methods were used to explore the relationships between these parameters and the compressive elastic behavior of the vertebrae, There was a 22% decrease in trabecular bone volume (TBV) and a 19% decline in mean trabecular thickness (Tb.Th) with OVX, This was accompanied by a 150% increase in trabecular connectivity, a result of the perforation of trabecular plates. Finite-element analysis of the trabecular bone removed from the cortical shell showed a 37% decline in the Young's modulus in compression after OVX with no appreciable change in the estrogen-treated group, The intact vertebrae (containing its trabecular bone) exhibited a 15% decrease in modulus with OVX, but this decline lacked statistical significance, OVX-induced changes in the trabecular architecture were different from those that have been observed in the proximal tibia, This difference was a consequence of the much more platelike structure of the trabecular bone in the vertebra.