HLA ANTIGENS IN OCULAR-TISSUES .1. INVIVO EXPRESSION IN HUMAN EYES
HLA ANTIGENS IN OCULAR-TISSUES .1. INVIVO EXPRESSION IN HUMAN EYES
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DOI：
10.1097/00007890-198803000-00021
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发表时间：
1988-03-01
期刊：
影响因子：
6.2
通讯作者：
WATKINS, S
中科院分区：
文献类型：
--
作者：
ABIHANNA, D;WAKEFIELD, D;WATKINS, S
眼睛是自身免疫性炎性疾病的常见部位，其中许多与HLA抗原有关。这些HLA表型在疾病过程中的作用目前尚不清楚。鉴于HLA抗原对免疫应答的重要性，了解HLA抗原在眼组织中的分布有助于我们了解这些抗原在疾病产生或易感性中的作用。除角膜外，人类眼组织中HLA抗原的表达尚未得到彻底研究。在这项研究中，我们研究了在体内表达的HLA抗原在死后人眼使用免疫组织化学技术。大多数眼细胞被发现不表达I类或II类HLA抗原，除了血管内皮细胞，这是一致的I类阳性。这些结果的意义进行了讨论，有关眼部免疫。
The eye is a common site for autoimmune inflammatory diseases, many of which are linked to HLA antigens. The role of these HLA phenotypes in the disease process is presently unknown. In view of the importance of HLA antigens to immune responses, a knowledge of the distribution of HLA antigens in ocular tissues may aid in our understanding of the role of these antigens in disease production or susceptibility. Apart from the cornea, the expression of HLA antigens in human ocular tissues has not been thoroughly investigated. In this study we examined the in vivo expression of HLA antigens in postmortem human eyes using immunohistochemical techniques. The majority of ocular cells were found not to express class I or class II HLA antigens, with the exception of the blood vessel endothelium, which was uniformly class I-positive. The significance of these results is discussed in relation to ocular immunity.