Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
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DOI：
10.1016/j.immuni.2004.05.007
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发表时间：
2004-06-01
期刊：
影响因子：
32.4
通讯作者：
Blumberg, RS
中科院分区：
文献类型：
--
作者：
Yoshida, M;Claypool, SM;Blumberg, RS
人胃肠道、呼吸道和生殖道的粘液分泌物含有大量的IgG。IgG到达管腔分泌物的机制以及IgG在这些位置的功能尚不清楚。在这里，我们发现，人新生儿Fc受体（FcRn）是运输IgG穿过肠上皮屏障进入管腔的车辆，在那里IgG可以结合同源抗原。然后，FcRn可以将IgG/抗原复合物再循环回肠屏障，进入固有层，由树突状细胞处理，并呈递给区域组织化淋巴结构中的CD 4（+）T细胞。这些结果解释了IgG如何分泌到粘膜表面并清除管腔抗原以供免疫系统识别。
Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The mechanism by which IgG reaches luminal secretions and the function of IgG in these locations are unknown. Here, we find that the human neonatal Fc receptor (FcRn) is the vehicle that transports IgG across the intestinal epithelial barrier into the lumen where the IgG can bind cognate antigen. The FcRn can then recycle the IgG/antigen complex back across the intestinal barrier into the lamina propria for processing by dendritic cells and presentation to CD4(+) T cells in regional organized lymphoid structures. These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system.