Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.
Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.
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DOI：
10.1016/j.placenta.2010.11.014
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发表时间：
2011-02
期刊：
影响因子：
3.8
通讯作者：
Piedrahita, J. A.
中科院分区：
文献类型：
--
作者：
Tsai, S.;Hardison, N. E.;James, A. H.;Motsinger-Reif, A. A.;Bischoff, S. R.;Thames, B. H.;Piedrahita, J. A.
胎盘在整个发育过程中作为胎儿营养和生长的调节剂发挥着重要作用，胎盘因素有助于妊娠异常，如先兆子痫。本研究描述了大量（n=60）人类胎盘的全基因组基因表达谱，以揭示与子痫前期相关的基因表达模式。除了证实与子痫前期相关的可溶性因子如sFLT1（可溶性fms样酪氨酸激酶-1）、sENG（可溶性内啡肽）和INHA（抑制素α）的表达变化外，我们还发现免疫相关信号通路的变化，为子痫前期发病中典型观察到的浅滋养细胞侵袭和子宫重构不足提供了潜在的上游解释。值得注意的是，我们还发现与子痫前期相关的胎盘唾液酸乙酰酯酶（SIAE）上调的证据，SIAE是一种与自身免疫性疾病功能相关的基因。
The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n=60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsiaassociated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.
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影响因子：
46.9
作者：
Canales, Roger D.;Luo, Yuling;Goodsaid, Federico M.
通讯作者：
Goodsaid, Federico M.
DOI：
10.1111/j.1471-0528.2000.tb11657.x
发表时间：
2000-11-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
Odegård, RA;Vatten, LJ;Austgulen, R
通讯作者：
Austgulen, R
用于预测先兆子痫的新型生物标志物。
影响因子：
9.3
作者：
Carty, David M.;Delles, Christian;Dominciczak, Anna F.
通讯作者：
Dominciczak, Anna F.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
168.9
作者：
ROBERTS, JM;REDMAN, CWG
通讯作者：
REDMAN, CWG