Classical conditioning of opioid activity in the fetal rat.
Classical conditioning of opioid activity in the fetal rat.
复制标题
胎鼠阿片类药物活性的经典调节。
DOI：
10.1037//0735-7044.108.5.951
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发表时间：
1994
影响因子：
1.9
通讯作者：
Robinson,SR
中科院分区：
文献类型：
--
作者：
Smotherman,WP;Robinson,SR
牛奶促进大鼠胚胎kappa阿片系统的活动，从而降低对皮肤刺激的反应性。在这项研究中，妊娠第20天的胎儿被提供了一个人工乳头(条件刺激；CS)和口腔内注入牛奶(非条件刺激；US)。一对CS和US在再次暴露于CS后降低了胎儿的反应性。阿片受体在条件反射后的选择性拮抗表明，阿片受体的反应性降低是由Mu阿片活性引起的。在3对CS和US并再次暴露于牛奶后，MU和Kappa阿片类药物活性明显。再暴露于CS或US后，条件反射过程中的Kappa阿片活性对于MU的参与是必要的。这些实验是在没有哺乳经验的胎儿身上进行的，表明在新生儿最初的乳头经历之后，哺乳过程中参与的神经化学系统可能会迅速改变。
Milk promotes activity in the kappa opioid system of the rat fetus that reduces responsiveness to cutaneous stimulation. In this study, fetuses on Gestational Day 20 were presented with an artificial nipple (conditioned stimulus; CS) paired with an intraoral infusion of milk (unconditioned stimulus; US). One paired presentation of the CS and US reduced fetal responsiveness after reexposure to the CS. Selective antagonism of opioid receptors after conditioning indicated that reduced responsiveness was due to mu opioid activity. Mu and kappa opioid activity was evident after 3 paired presentations of CS and US and reexposure to milk. Kappa opioid activity during conditioning was necessary for mu involvement after reexposure to the CS or US. These experiments, which were conducted with fetal subjects that lacked suckling experience, suggest that neurochemical systems engaged during suckling may change rapidly after the newborn's initial experiences at the nipple.