Parafibromin expression in lung normal tissue and carcinoma: its comparison with clinicopathological parameters of carcinoma
Parafibromin expression in lung normal tissue and carcinoma: its comparison with clinicopathological parameters of carcinoma
复制标题
肺正常组织和癌中的副纤维蛋白表达：与癌临床病理参数的比较
DOI：
10.14670/hh-26.1039
复制
发表时间：
2011-08-01
影响因子：
2
通讯作者：
Zheng, Hua-chuan
中科院分区：
文献类型：
--
作者：
Xia, Pu;Wang, Wei;Zheng, Hua-chuan
Parafibromin is a protein encoded by the hyperparathyroidism 2 oncosuppressor gene and its down-regulated expression is involved in the pathogenesis of parathyroid, gastric and colorectal carcinomas. To clarify the roles of parafibromin expression in lung carcinomas, it was examined by immunohistochemistry and in situ hybridization on tissue microarray containing lung carcinomas (n=144) and normal lung tissue (n=20), with a comparison to clinicopathological parameters of carcinomas. Lung carcinoma cell lines and tissues were studied for parafibromin expression by Western blot and RT-PCR. Down-regulated expression of parafibromin mRNA was found in lung carcinoma in comparison with matched normal tissue (p0.05). The Kaplan-Meier method indicated that nuclear parafibromin expression was positively correlated with adenocarcinoma patients (p
