TISSUE CONCENTRATIONS OF MPTP AND MPP+ IN RELATION TO CATECHOLAMINE DEPLETION AFTER THE ORAL OR SUBCUTANEOUS ADMINISTRATION OF MPTP TO MICE
TISSUE CONCENTRATIONS OF MPTP AND MPP+ IN RELATION TO CATECHOLAMINE DEPLETION AFTER THE ORAL OR SUBCUTANEOUS ADMINISTRATION OF MPTP TO MICE
复制标题
DOI：
10.1016/0024-3205(89)90072-6
复制
发表时间：
1989-01-01
期刊：
影响因子：
6.1
通讯作者：
PERRY, KW
中科院分区：
文献类型：
--
作者：
FULLER, RW;HEMRICKLUECKE, SK;PERRY, KW
以30 mg/kg的剂量皮下给予小鼠MPTP一小时后，其在组织中的浓度变化顺序为肾>肝>肺>脑>心脏。当口服相同剂量的 MPTP 时，大多数组织中的浓度在 1 小时时比皮下注射后低得多。给药后，尽管肝脏中的 MPTP 浓度仅略有降低。除肾脏外，所有组织中1小时时MPP+（MPTP的代谢物）浓度均与MPTP一样高或更高，并且MPP+从各组织中消失，半衰期为3-20小时。 MPP+ 的绝对浓度和相对于 MPTP 的最高浓度都在心脏中。口服MPTP后，脑内未发现MPP+，其他组织中MPP+浓度均低于皮下注射后的浓度。剂量。尽管口服给药后心脏中的 MPTP 和 MPP+ 浓度较低，但通过任一给药途径施用 MPTP 后，心脏去甲肾上腺素的消耗相似，这表明 MPTP 的其他代谢物也可能导致心脏去甲肾上腺素消耗。
One hour after MPTP wa given to mice at a dose of 30 mg/kg s.c., its concentrations in tissues varied in the order kidney > liver > lung > brain > heart. When the same dose of MPTP was given orally, concentrations in most tissues were much lower at 1 hr than after s.c. administration, although the MPTP concentration in liver was only slightly lower. The concentrations of MPP+ (a metabolite of MPTP) at 1 hr were as high or higher than those of MPTP in all tissues except kidney, and MPP+ disappeared from the various tissues with half-lives from 3-20 hrs. The highest concentrations of MPP+, both absolute and relative to MPTP, were in heart. After oral administration of MPTP, no MPP+ was found in brain, and MPP+ concentrations in other tissues were lower than those after s.c. dosing. The depletion of heart norepinephrine was similar after MPTP administration by either route of administration even though MPTP and MPP+ concentrations in heart were lower after oral administration, suggesting that other metabolites of MPTP might also contribute to heart norepinephrine depletion.