Voice Onset Time in Early- and Late-Stage Amyotrophic Lateral Sclerosis.
Voice Onset Time in Early- and Late-Stage Amyotrophic Lateral Sclerosis.
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早期和晚期肌萎缩侧索硬化症的发声时间。
DOI：
10.1044/2022_jslhr-21-00632
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Wang,Jun
中科院分区：
文献类型：
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作者：
Thomas,Anusha;Teplansky,KristinJ;Wisler,Alan;Heitzman,Daragh;Austin,Sara;Wang,Jun
目的肌萎缩侧索硬化症（Amyotrophiclateralsclerosis，ALS）是一种影响延髓功能的神经退行性疾病.方法对11例早期ALS患者（n= 11）、6例晚期ALS患者（n= 6）和13例健康对照者（n= 13）的非词/bap/发音进行语音起始时间（VOT）测定，结果三组间VOT值的总体比较显示出显著差异，F（2，27）= 11.71，p <0.01。在后期ALS的扬声器显示较长的发声铅（负VOT）比健康的扬声器和扬声器在早期ALS。VOT也与言语表现显著负相关（即，可理解说话率），r（15）= 0.74，p <0.01。结论ALS越严重者，浊音导联出现率越高，浊音导联越长。研究结果表明发声先于发音发病与疾病进展的生产双唇停止，这表明，在ALS的后期阶段的喉上结构和发声系统之间的协调的相对时间受到影响。
PurposeAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects bulbar functions including speech and voice. Voice onset time (VOT) was examined in speakers with ALS in early and late stages to explore the coordination of the articulatory and phonatory systems during speech production.MethodVOT was measured in nonword /bap/ produced by speakers with early-stage ALS (n= 11), late-stage ALS (n= 6), and healthy controls (n= 13), and compared with speech performance decline (a marker of disease progression) in ALS.ResultsOverall comparison of the VOT values among the three groups showed a significant difference,F(2,27) = 11.71,p< .01. Speakers in late-stage ALS displayed longer voicing lead (negative VOT) than both healthy speakers and speakers in early-stage ALS. VOT was also significantly negatively correlated with speech performance (i.e., Intelligible Speaking Rate),r(15) = .74,p< .01.ConclusionsSpeakers with more severe ALS showed greater occurrence of voicing lead and longer voicing lead. Findings show voicing precedes articulatory onset with disease progression in the production of bilabial stops, which suggests that the relative timing of coordination between the supralaryngeal structures and the phonatory system is affected in the late stage of ALS.