Beta-L-1,3-dioxolane-cytidine: a novel nucleoside that inhibits proliferation and induces differentiation of keratinocytes in vitro.
Beta-L-1,3-dioxolane-cytidine: a novel nucleoside that inhibits proliferation and induces differentiation of keratinocytes in vitro.
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Beta-L-1,3-二氧戊环-胞苷：一种新型核苷，可在体外抑制角质形成细胞增殖并诱导分化。
DOI：
10.1159/000029829
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Cheng,YC
中科院分区：
文献类型：
--
作者：
Schwartz,PM;Haggerty,JG;Cheng,YC
β-L-1,3-Dioxolane-cytidine (L-(–)-OddC) is a novelL-nucleoside, and its antitumor activity is under investigation in clinical trials. To evaluate the potential ofL-(–)-OddC for treating hyperproliferative diseases of the skin, we examined its activity in human keratinocytes in vitro. The dose ofL-(–)-OddC that inhibited the rate of proliferation of keratinocytes by 50% was 50 nM.L-(–)-OddC was about as cytotoxic as 9-β-D-arabinofuranosylcytosine but was about 1,000 time more potent than 3′-azidothymidine.L-(–)-OddC caused irreversible growth arrest and induced differentiation of keratinocytes.L-(–)-OddC altered morphology, increased the cell size of keratinocytes and increased the expression of involucrin. These data suggest thatL-(–)-OddC may have potential as a therapeutic agent against hyperproliferative skin diseases.
