Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice
Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice
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DOI：
10.1038/mi.2015.38
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发表时间：
2016-01-01
影响因子：
8
通讯作者：
Hauser, A. E.
中科院分区：
文献类型：
--
作者：
Lemke, A.;Kraft, M.;Hauser, A. E.
在全身免疫应答期间，血浆母细胞在次级淋巴器官中产生并迁移到骨髓，在那里它们可以变得长寿，负责维持长期抗体滴度。血浆母细胞是小肠粘膜免疫反应中产生的，位于固有层（LP），主要产生免疫球蛋白A。这些抗体分泌细胞的迁移在急性免疫应答期间被充分表征。关于它们的寿命和对长寿骨髓室的贡献知之甚少。在这里，我们调查的血浆细胞（PC）的寿命和口服免疫后肠道和骨髓的PC隔间之间的关系。我们的研究结果表明，在LP的PC可以存活很长一段时间。免疫后至少9个月，可在骨髓中检测到口服抗原特异性PC，表明粘膜PC隔室可有助于该器官中的长寿命PC池，而不依赖于脾B细胞的参与。我们的研究结果表明，粘膜和全身PC池之间的区室化不像以前认为的那么严格。这可能对疫苗的开发以及自身抗体介导的疾病有影响。
During systemic immune responses, plasma blasts are generated in secondary lymphoid organs and migrate to the bone marrow, where they can become long-lived, being responsible for the maintenance of long-term antibody titers. Plasma blasts generated in mucosal immune responses of the small intestinehome to the lamina propria (LP), producing mainly immunoglobulin A. The migration of these antibody-secreting cells is well characterized during acute immune responses. Less is known about their lifetime and contribution to the long-lived bone marrow compartment. Here we investigate the lifetime of plasma cells (PCs) and the relationship between the PC compartments of the gut and bone marrow after oral immunization. Our findings indicate that PCs in the LP can survive for extended time periods. PCs specific for orally administered antigens can be detected in the bone marrow for at least 9 months after immunization, indicating that the mucosal PC compartment can contribute to the long-lived PC pool in this organ, independent of the participation of splenic B cells. Our findings suggest that the compartmentalization between mucosal and systemic PC pools is less strict than previously thought. This may have implications for the development of vaccines as well as for autoantibody-mediated diseases.