Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
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高电荷钌(II)聚吡啶配合物作为溶酶体定位光敏剂用于双光子光动力疗法
DOI：
10.1002/anie.201507800
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发表时间：
2015-11-16
影响因子：
16.6
通讯作者：
Chao, Hui
中科院分区：
文献类型：
--
作者：
Huang, Huaiyi;Yu, Bole;Chao, Hui
光动力疗法（PDT）是一种非侵入性医疗技术，近年来受到越来越多的关注，并应用于治疗某些类型的癌症。然而，目前临床上使用的PDT试剂除了在800 nm左右的双光子截面非常低之外，还存在一些局限性，例如水溶性低、光稳定性差、对癌细胞的选择性有限，这限制了它们在TP-PDT中的潜在应用。为了解决这些缺点，合成了三种带高正电荷的钌(II)聚吡啶配合物。这些复合物选择性地定位在溶酶体中，这是 PDT 目的的理想定位。其中一种复合物在 3D HeLa 多细胞肿瘤球体中在 800 nm 照射下表现出令人印象深刻的光毒性指数，因此在双光子光动力治疗中具有广阔的应用前景。
Photodynamic therapy (PDT) is a noninvasive medical technique that has received increasing attention over the last years and been applied for the treatment of certain types of cancer. However, the currently clinically used PDT agents have several limitations, such as low water solubility, poor photostability, and limited selectivity towards cancer cells, aside from having very low two-photon cross-sections around 800 nm, which limits their potential use in TP-PDT. To tackle these drawbacks, three highly positively charged ruthenium(II) polypyridyl complexes were synthesized. These complexes selectively localize in the lysosomes, an ideal localization for PDT purposes. One of these complexes showed an impressive phototoxicity index upon irradiation at 800 nm in 3D HeLa multicellular tumor spheroids and thus holds great promise for applications in two-photon photodynamic therapy.