Physiological increments in epinephrine stimulate metabolic rate in humans.
Physiological increments in epinephrine stimulate metabolic rate in humans.
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肾上腺素的生理增加会刺激人体的新陈代谢率。
DOI：
10.1152/ajpendo.1987.253.3.e322
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Bier,DM
中科院分区：
文献类型：
--
作者：
Staten,MA;Matthews,DE;Cryer,PE;Bier,DM
众所周知，血浆肾上腺素显著升高会增加代谢率（MR），但这种水平的肾上腺素在正常自由生活的受试者中很少遇到。我们研究了日常活动中常见的肾上腺素水平是否会影响MR，从而可能调节热量消耗。为了帮助定义MR阈值，我们首先在没有任何干预的情况下，通过间接量热法在6个不同场合测量4个人的MR，测量了个体内MR的每小时和每日变化。我们发现每小时的变化（2.0 +/- 0.9%）和每天的变化（2.7 +/- 0.9%）都很低，因此可以自信地检测肾上腺素输注期间代谢率的小增量。为了确定肾上腺素增加MR作用的阈值，我们在四个不同的场合研究了五个正常体重的吸收后年轻男性。在每5小时研究周期的第1小时，静脉滴注生理盐水。然后，在随后的4小时内，受试者接受0.1、0.5和1.0微克/分钟（随机）的生理盐水或肾上腺素静脉输注。最低肾上腺素输注率（静脉血浆浓度94 +/- 32 pg/ml）时，MR显著升高（3.6 +/- 1.0% SE）。MR升高与血浆肾上腺素升高相关（r = 0.85, P < 0.001）。肾上腺素影响MR的阈值浓度（95%置信上限）为90 pg/ml，这是日常生活中经常出现的浓度。因此，肾上腺素可能通过影响能量消耗在维持体重方面发挥重要作用。
Markedly elevated plasma epinephrine is known to increase metabolic rate (MR), but such levels of epinephrine are encountered infrequently in normal free-living subjects. We studied whether epinephrine levels common in usual daily activities can affect MR and thus possibly regulate caloric expenditure. To aid definition of a MR threshold, we first measured the hourly and daily variation in MR within individuals by measuring the MR of four individuals by indirect calorimetry for 6 h on six separate occasions without any intervention. We found that hour-to-hour variation (2.0 +/- 0.9%) and the day-to-day variation (2.7 +/- 0.9%) were low, thus allowing confident detection of small increments in metabolic rate during epinephrine infusion. To define a threshold for epinephrine's effect to increase MR, we studied five normal-weight postabsorptive young men on four separate occasions. During the 1st h of each 5-h study period, saline was infused intravenously. Then, during the subsequent 4 h, subjects received intravenous infusion of saline or epinephrine at 0.1, 0.5, and 1.0 microgram/min (randomized). A significant increase in MR (3.6 +/- 1.0% SE) was measured with the lowest epinephrine infusion rate (venous plasma concentration, 94 +/- 32 pg/ml). The increases in MR correlated (r = 0.85, P less than 0.001) with increases in plasma epinephrine. The threshold concentration (upper 95% confidence limit) of epinephrine to affect MR was 90 pg/ml, a concentration frequently occurring in daily life. Thus epinephrine may play an important role in weight maintenance by affecting energy expenditure.