Brain health and shared risk factors for dementia and stroke
Brain health and shared risk factors for dementia and stroke
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DOI：
10.1038/nrneurol.2015.195
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发表时间：
2015-11-01
影响因子：
38.1
通讯作者：
Sacco, Ralph L.
中科院分区：
文献类型：
--
作者：
Gardener, Hannah;Wright, Clinton B.;Sacco, Ralph L.
脑健康受损包括一系列临床结果，包括中风、痴呆、血管性认知障碍、认知老化和血管功能障碍。与大脑健康状况不佳相关的疾病是全球发病率和死亡率的主要原因，预计随着人口老龄化，公共卫生负担将增加。许多血管风险因素是大脑健康状况不佳的共同预测因素。此外，亚临床脑MRI血管损伤标志物是卒中和痴呆之间共有的危险因素，可用于风险分层和早期干预。大脑健康的广泛概念导致了从血管风险因素到大脑健康决定因素的概念转变。通过针对可改变的风险因素来减少心血管疾病的全球运动是必要的，并将对大脑健康产生广泛影响。需要对大脑健康状况的不同和重叠病因进行研究，并定义MRI标记物，以帮助临床医生识别将从积极的预防措施中受益的患者。
Impaired brain health encompasses a range of clinical outcomes, including stroke, dementia, vascular cognitive impairment, cognitive ageing, and vascular functional impairment. Conditions associated with poor brain health represent leading causes of global morbidity and mortality, with projected increases in public health burden as the population ages. Many vascular risk factors are shared predictors for poor brain health. Moreover, subclinical brain MRI markers of vascular damage are risk factors shared between stroke and dementia, and can be used for risk stratification and early intervention. The broad concept of brain health has resulted in a conceptual shift from vascular risk factors to determinants of brain health. Global campaigns to reduce cardiovascular diseases by targeting modifiable risk factors are necessary and will have a broad impact on brain health. Research is needed on the distinct and overlapping aetiologies of brain health conditions, and to define MRI markers to help clinicians identify patients who will benefit from aggressive prevention measures.