In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas
In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas
复制标题
人脑胶质瘤中葡萄糖氧化代谢的体内紊乱
作者：
C. Rhodes;R. Wise;J. Gibbs;Richard S. J. Frackowiak;J. Hatazawa;A. Palmer;D. Thomas;T. Jones
应用正电子发射断层扫描技术对7例人脑胶质瘤患者的葡萄糖氧化代谢异常进行了研究。使用氧-15稳态吸入技术测量局部脑血流量和耗氧量。使用氟18标记的2-氟-2-脱氧-D-葡萄糖和简化的Sokoloff方法获得局部脑葡萄糖消耗值。获得对侧皮质大脑中动脉区域的肿瘤和脑组织的功能值。使用正常脑组织引用的集总常数值（0.42）计算两个区域的局部葡萄糖消耗值。
Abnormalities in the oxidative metabolism of glucose in human cerebral gliomas have been studied in seven patients using positron emission tomography. Measurements of regional cerebral blood flow and oxygen consumption were obtained using the oxygen‐15 steady‐state inhalation technique. Values of regional cerebral glucose consumption were obtained using fluorine 18–labeled 2‐fluoro‐2‐deoxy‐D‐glucose and a simplification of the method of Sokoloff. Functional values were obtained for regions of tumor and brain tissue in the middle cerebral artery territory of the contralateral cortex. Values of regional glucose consumption were calculated for both regions using a value of the lumped constant quoted for normal brain tissue (0.42).
DOI：
10.1016/j.ijheatmasstransfer.2015.11.061
发表时间：
2016-03-01
影响因子：
5.2
作者：
Hsieh, Shou-Shing;Liu, Hao-Hsiang;Yeh, Yi-Fan
通讯作者：
Yeh, Yi-Fan