Catecholamine sensitivities of neurons related to a visual reaction time task in the monkey prefrontal cortex.
Catecholamine sensitivities of neurons related to a visual reaction time task in the monkey prefrontal cortex.
复制标题
与猴子前额皮质视觉反应时间任务相关的神经元儿茶酚胺敏感性。
DOI：
10.1152/jn.1987.58.5.1100
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发表时间：
1987
影响因子：
2.5
通讯作者：
T. Sawaguchi
中科院分区：
文献类型：
--
作者：
T. Sawaguchi
1. 利用微离子吸附技术和有意识的猴子，研究了在视觉反应时间任务中显示活动变化的前额叶皮层（PFC）神经元对去甲肾上腺素（NA）和多巴胺（DA）的敏感性。视觉反应时间任务由按下杠杆开始，包括四个阶段：初始等待阶段3.0 s，警告阶段（绿灯1.5-3.5 s），杠杆释放阶段（红灯）和最终奖励阶段。2. 总共有153个神经元在任务的一个或两个阶段表现出活动的变化。在这些神经元中，39个在警告阶段改变了它们的活动，48个在围棋阶段改变了它们的活动，38个在警告和围棋阶段都改变了它们的活动，28个在奖励阶段改变了它们的活动。3. 在153个与任务相关的神经元中，141个神经元的兴奋性和/或抑制性反应被离子导电地施加NA和DA（电流为30-70 NA，但通常为50 NA）。NA诱导了99个神经元的反应，这些反应主要是抑制性的（n = 90）。DA诱导了92个神经元的兴奋性（n = 62）和抑制性（n = 30）反应。50个神经元对NA和DA均敏感。4. 在任务的不同阶段表现出活性变化的神经元对50 NA的NA和DA的敏感性不同。预警期相关神经元对NA主要敏感（36/39），go期相关神经元对DA主要敏感（44/48），预警期和go期相关神经元对NA和DA都敏感（33/38），奖励期相关神经元对NA主要敏感（23/28）。5. 在警告阶段活动变化增加的神经元中，NA对背景活动的降低程度大于警告阶段的活动，并增加了与警告阶段相关的活动与背景活动的比值。在预警期变化减少的神经元中，NA对预警期活动的抑制程度大于背景活动，并增加了背景活动与预警期相关活动的比值。此外，应用NA后，活性变化的潜伏期有缩短的趋势。因此，NA增强了预警期活动的变化，无论变化的方向是增加还是减少。（摘要删节为400字）
1. Using microiontophoretic techniques and conscious monkeys, sensitivities to noradrenaline (NA) and dopamine (DA) of neurons of the prefrontal cortex (PFC), which showed changes in activity during a visual reaction time task, were investigated. The visual reaction time task was initiated by the pressing of a lever and consisted of four phases: an initial waiting phase of 3.0 s, a warning phase (green light of variable duration of 1.5-3.5 s), a lever release go phase (red light), and a final reward phase. 2. A total of 153 neurons, which showed changes in activity during one or two phase(s) of the task, were sampled. Of these neurons, 39 changed their activity during the warning phase, 48 changed their activity during the go phase, 38 changed their activity during both the warning and the go phases, and 28 changed their activity during the reward phase. 3. Iontophoretically applied NA and DA (with a current of 30-70 nA, but usually with a current of 50 nA) induced excitatory and/or inhibitory responses in 141 of the 153 task-related neurons. NA induced responses in 99 neurons, and these responses were predominantly inhibitory (n = 90). DA induced excitatory (n = 62) and inhibitory (n = 30) responses in 92 neurons. Fifty neurons were sensitive to both NA and DA. 4. The neurons showing changes in activity during different phases of the task showed different sensitivities to NA and DA applied with 50 nA. The warning phase-related neurons were primarily sensitive to NA (36/39), the go phase-related neurons were primarily sensitive to DA (44/48), neurons related to both the warning and go phases were sensitive to both NA and DA (33/38), and the reward phase-related neurons were primarily sensitive to NA (23/28). 5. In the neurons that showed increased changes in activity during the warning phase, NA reduced the background activity to a greater extent than the activity during the warning phase and increased the ratio of the warning phase-related activity to the background activity. In the neurons that showed decreased changes during the warning phase, NA reduced the activity during the warning phase to a great extent than the background activity, and increased ratio of the background activity to the warning phase-related activity. Furthermore, the latency of onset of the change in activity tended to become shorter by application of NA. Thus, NA enhanced the change in activity during the warning phase, irrespective of whether the direction of the change was toward an increase or a decrease.(ABSTRACT TRUNCATED AT 400 WORDS)