Role of MAP1B in axonal retrograde transport of mitochondria
Role of MAP1B in axonal retrograde transport of mitochondria
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DOI：
10.1042/bj20060205
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发表时间：
2006-07-01
影响因子：
4.1
通讯作者：
Avila, Jesus
中科院分区：
文献类型：
--
作者：
Jimenez-Mateos, Eva-Maria;Gonzalez-Billault, Christian;Avila, Jesus
MAP(微管相关蛋白)MAP1B和tau是众所周知的与微管结合并稳定这些结构的蛋白。最近出现了MAP的另一个作用，它们似乎参与了轴突中发现的微管上的货物运输的调节。在这一角色中，tau与顺行轴突运输的调节有关。我们现在报告MAP1B与线粒体逆行轴突运输的调节有关。这一发现潜在地通过MAP在几个层面上提供了对轴突运输的精确控制：根据所涉及的MAP的类型控制运输的顺行或逆行方向，控制运输的速度和控制发生运输的微管轨迹的稳定性。
The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occurs.