Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
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DOI：
10.3389/fnut.2022.941097
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发表时间：
2022
影响因子：
5
通讯作者：
Zhong, Jing
中科院分区：
文献类型：
--
作者：
Zhang, Jinlin;Luo, Wenchen;Miao, Changhong;Zhong, Jing
关键词：
由于重症监护病房的发展，许多患者在最初的侮辱中幸存下来，但进展为慢性危重疾病（CCI）。CCI患者的特点是住院时间长，预后差，长期死亡率高。其中部分患者进入持续性低度炎症、免疫抑制和持续分解代谢状态，2012年将其定义为持续性炎症、免疫抑制和分解代谢综合征（PICS）。在过去几年中，PICS的治疗取得了一些进展。然而，现有的研究大多是关于持续炎症和免疫抑制在PICS中的作用。作为PICS的标志之一，高分解代谢很少受到研究的关注。在这篇综述中，我们探讨了高分解代谢的潜在病理生理变化和分子机制及其在PICS中的作用。此外，我们总结了目前改善PICS患者高分解代谢状态的治疗方法和建议。
Owing to the development of intensive care units, many patients survive their initial insults but progress to chronic critical illness (CCI). Patients with CCI are characterized by prolonged hospitalization, poor outcomes, and significant long-term mortality. Some of these patients get into a state of persistent low-grade inflammation, suppressed immunity, and ongoing catabolism, which was defined as persistent inflammation, immunosuppression, and catabolism syndrome (PICS) in 2012. Over the past few years, some progress has been made in the treatment of PICS. However, most of the existing studies are about the role of persistent inflammation and suppressed immunity in PICS. As one of the hallmarks of PICS, hypercatabolism has received little research attention. In this review, we explore the potential pathophysiological changes and molecular mechanisms of hypercatabolism and its role in PICS. In addition, we summarize current therapies for improving the hypercatabolic status and recommendations for patients with PICS.
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