Aurora B kinases restrict chromosome decondensation to telophase of mitosis
Aurora B kinases restrict chromosome decondensation to telophase of mitosis
复制标题
DOI：
10.4161/cc.7.3.5381
复制
发表时间：
2008-02-01
期刊：
影响因子：
4.3
通讯作者：
Clarke, Duncan J.
中科院分区：
文献类型：
--
作者：
Vas, Amit C. J.;Clarke, Duncan J.
Aurora激酶包括一个进化保守的丝氨酸/苏氨酸激酶家族，在中心体复制、有丝分裂纺锤体组装、染色体凝聚、纺锤体上的染色体双向定位和染色体分离中具有重要功能。脊椎动物有三种极光激酶，分别是极光a- a、-B和-C，而无脊椎动物只有极光a- a和-B，酵母只有一种极光激酶，即S. cerevisiae中的Ipl1和S. pombe中的Ark1。最近，极光激酶在染色体凝聚中的作用已经被明确；Aurora B在后期染色体轴向缩短中起着至关重要的作用，可能是为了防止染色体臂被困在细胞动力学板内。
The Aurora kinases comprise a family of evolutionary conserved serine/ threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome segregation. Vertebrates have three Aurora kinases, Aurora-A, -B and -C, while invertebrates have only Aurora-A and -B and yeasts have a single Aurora kinase, Ipl1 in S. cerevisiae and Ark1 in S. pombe. Recently, the role of Aurora kinases in chromosome condensation has been defined; Aurora B plays a crucial role in the axial shortening of chromosomes during anaphase, presumably in order to prevent chromosome arms from becoming trapped within the cytokinetic plate.