Facile technique for preparing organic–inorganic composite particles: Monodisperse poly(lactide-co-glycolide) (PLGA) particles having silica nanoparticles on the surface
Facile technique for preparing organic–inorganic composite particles: Monodisperse poly(lactide-co-glycolide) (PLGA) particles having silica nanoparticles on the surface
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DOI：
10.1016/j.colsurfa.2010.03.019
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发表时间：
2010-05
期刊：
影响因子：
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通讯作者：
F. Ito;Y. Uchida;Y. Murakami
中科院分区：
文献类型：
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作者：
F. Ito;Y. Uchida;Y. Murakami
本文介绍了一种制备有机-无机复合粒子的简便方法。该技术涉及在单分散PLGA颗粒表面涂覆50 nm二氧化硅纳米球作为模型复合材料。首先采用Shirasu多孔玻璃（SPG）膜乳化技术和溶剂蒸发法制备了分子量（Mw）为5000、10，000、15，000和20，000的单分散聚（丙交酯-共-乙交酯）（PLGA）颗粒（尺寸：2.0μm）。还通过改变所用SPG膜的孔径制备单分散PLGA颗粒（尺寸：0.70、1.00、2.00和3.00μm，Mw：20，000）。制备的PLGA颗粒的表面通过吸附具有抗衡离子的阴离子来改性，这导致从原始阴离子颗粒形成带正电的PLGA颗粒。二氧化硅纳米球（尺寸：50 nm）通过静电相互作用包覆在改性后的PLGA粒子表面，制备有机-无机复合粒子。与单纯的PLGA粒子相比，所制备的复合粒子具有独特的生物应用功能。
This paper presents a facile technique for preparing organic–inorganic composite particles. The technique involves coating 50-nm silica nanospheres as model composites on the surface of monodisperse PLGA particles. Monodisperse poly(lactide-co-glycolide) (PLGA) particles (size: 2.0μm) with molecular weights (Mw) of 5000, 10,000, 15,000, and 20,000 are first prepared using a Shirasu porous glass (SPG) membrane emulsification technique and a solvent evaporation method. Monodisperse PLGA particles (sizes: 0.70, 1.00, 2.00, and 3.00μm, Mw: 20,000) are also prepared by varying the pore size of the SPG membrane used. The surfaces of the prepared PLGA particles are modified by the adsorption of a polyelectrolyte having counter-ions, which results in the formation of positively charged PLGA particles from the original anionic particles. Silica nanospheres (size: 50nm) are coated on the surface of the modified PLGA particles via electrostatic interaction in order to prepare the organic–inorganic composite particles. Compared with simple PLGA particles, the prepared composite particles have a unique functionality for biological applications.