Structural Tuning and Conformational Stability of Aromatic Oligoamide Foldamers
Structural Tuning and Conformational Stability of Aromatic Oligoamide Foldamers
复制标题
DOI：
10.1002/chem.201703985
复制
发表时间：
2017-11-21
影响因子：
4.3
通讯作者：
Nissinen, Maija
中科院分区：
文献类型：
--
作者：
Annala, Riia;Suhonen, Aku;Nissinen, Maija
合成了一系列以2个或3个吡啶-2，6-二甲酰胺单元为主要折叠基元，以不同芳香结构单元为连接基的芳香低聚酰胺折叠体，研究了结构变化对折叠性能和构象稳定性的影响.晶体学研究表明，在固态下，中心连接体单元要么延长螺旋和更开放的S形构象，将螺旋压缩成更紧凑的构象，要么充当分隔吡啶-2，6-二甲酰胺单元的刚性间隔物，这对于它们而言增加了构象性质的可预测性。多维NMR研究表明，即使在溶液中，折叠体显示构象稳定性和折叠构象的固态结构。
A series of aromatic oligoamide foldamers with two or three pyridine-2,6-dicarboxamide units as their main folding motifs and varying aromatic building blocks as linkers have been synthetized to study the effects of the structural variation on the folding properties and conformational stability. Crystallographic studies showed that in the solid state the central linker unit either elongates the helices and more open S-shaped conformations, compresses the helices to more compact conformations, or acts as a rigid spacer separating the pyridine-2,6-dicarboxamide units, which for their part add the predictability of the conformational properties. Multidimensional NMR studies showed that, even in solution, foldamers show conformational stability and folded conformations comparable to the solid-state structures.