Osteoconductive Potential of Mesoporous Titania Implant Surfaces Loaded with Magnesium: An Experimental Study in the Rabbit
Osteoconductive Potential of Mesoporous Titania Implant Surfaces Loaded with Magnesium: An Experimental Study in the Rabbit
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DOI：
10.1111/cid.12211
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发表时间：
2015-12-01
影响因子：
3.6
通讯作者：
Jimbo, Ryo
中科院分区：
文献类型：
--
作者：
Galli, Silvia;Naito, Yoshihito;Jimbo, Ryo
背景：介孔涂层能够掺入功能物质并在植入部位持续释放它们。一种可以掺入介孔的生物活性物质是镁，它强烈参与骨代谢和成骨细胞相互作用。目的：本实验研究的目的是评估将镁掺入口腔种植体介孔涂层对骨整合早期阶段的影响。材料和方法：钛种植体涂有孔径为 6 nm 的介孔 TiO2 薄膜，并负载镁。通过干涉测量、原子力显微镜、扫描电子显微镜和能量色散光谱对植入物表面进行了广泛的表征，然后将其植入 10 只兔子的胫骨中。愈合 3 周后，通过移除扭矩测试以及组织学和组织形态计量学评估骨整合。结果：组织学和生物力学分析显示种植体没有副作用并且骨整合成功。生物力学评估证明镁掺杂对强化种植体-骨界面具有显着效果。结论：镁从种植体表面局部释放可增强愈合早期（种植后 3 周）的种植体固位，这对于种植体的早期负重非常理想。
Background: Mesoporous coatings enable incorporation of functional substances and sustainedly release them at the implant site. One bioactive substance that can be incorporated in mesoporous is magnesium, which is strongly involved in bone metabolism and in osteoblast interaction.Purpose: The aim of this experimental study was to evaluate the effect of incorporation of magnesium into mesoporous coatings of oral implants on early stages of osseointegration.Material and Methods: Titanium implants were coated with thin films of mesoporous TiO2 having pore diameters of 6 nm and were loaded with magnesium. The implant surfaces were extensively characterized by means of interferometry, atomic force microscopy, scanning electron microscopy, and energy-dispersive spectroscopy and then placed in the tibiae of 10 rabbits. After 3 weeks of healing, osseointegration was evaluated by means of removal torque testing and histology and histomorphometry.Results: Histological and biomechanical analyses revealed no side effects and successful osseointegration of the implants. The biomechanical evaluation evidenced a significant effect of magnesium doping on strengthening the implant-bone interface.Conclusions: A local release of magnesium from the implant surfaces enhances implant retention at the early stage of healing (3 weeks after implantation), which is highly desirable for early loading of the implant.