Immunohistochemical demonstration of several tumour markers in neoplastic and preneoplastic states of the uterine mucosa.
Immunohistochemical demonstration of several tumour markers in neoplastic and preneoplastic states of the uterine mucosa.
复制标题
子宫粘膜肿瘤和肿瘤前状态下几种肿瘤标志物的免疫组织化学演示。
DOI：
10.1159/000300966
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发表时间：
1978
影响因子：
2.1
通讯作者：
J. Hustin
中科院分区：
文献类型：
--
作者：
J. Hustin
对不同病理状态的子宫粘膜进行五种肿瘤标志物（CEA、AFP、κ-酪蛋白、总 HCG 及其 β 亚基）的酶免疫细胞化学验证。 CEA经常存在于非典型增生区域和60%以上的癌症中。相反，κ-酪蛋白是囊性增生中意外但常见的发现。其他抗原在组织中未检测到或异常检测到。我们相信，CEA 检测可能是描绘子宫内膜癌前变化的非常有用的工具，而 kappa-酪蛋白“储存细胞”的存在可能表明雌激素作用不受阻碍。
Enzymic immunocytochemical demonstration of five tumour markers (CEA, AFP, kappa-casein, total HCG and its beta-subunit) was performed on various pathological states of the uterine mucosa. CEA was constantly found in areas of atypical hyperplasia and in more than 60% of cancers. kappa-Casein on the contrary was an unexpected but frequent finding in cystic hyperplasia. The other antigens were not, or exceptionally, detected in the tissues. We believe that CEA detection may be a very useful tool in delineating preneoplastic changes of the endometrium while the presence of kappa-casein "storing cells" might point to an unopposed estrogen action.