Role of contractile agonists in growth regulation of vascular smooth muscle cells.
Role of contractile agonists in growth regulation of vascular smooth muscle cells.
复制标题
收缩激动剂在血管平滑肌细胞生长调节中的作用。
DOI：
10.1007/978-1-4684-6015-5_6
复制
发表时间：
1991
影响因子：
--
通讯作者：
Owens,GK
中科院分区：
文献类型：
--
作者：
Owens,GK
加速平滑肌生长是高血压患者和动物动脉的一个特征性特征（1,15,26,27,36,40）。在阻力血管中，这种平滑肌的加速生长有助于内侧增厚或肥大的发展，并被认为在高血压的病因中起重要作用（1,13）。据推测，内侧肥大具有机械优势，因此在任何给定的平滑肌激活水平下，高血压患者的血管阻力都大于对照组（12,25）。然而，应该注意的是，内侧肥大似乎并不发生在非常小的动脉（内径< 100克）和小动脉中，而只限于大动脉和中等大小的阻力动脉（即内径150-300克）（8,19,26,40）。广泛的内侧肥厚发生在大导管血管，如主动脉（33）。在这些血管中，内侧肥大被认为是一种适应性过程，以尽量减少由于血压升高而引起的壁应力变化（34）。
Accelerated smooth muscle growth is a characteristic feature in arteries of hypertensive patients and animals (1,15,26,27,36,40). In resistance vessels, this accelerated growth of smooth muscle contributes to development of medial thickening or hypertrophy and is thought to play an important role in the etiology of hypertension (1,13). It is hypothesized that medial hypertrophy confers a mechanical advantage such that at any given level of smooth muscle activation vascular resistance is greater in hypertensives than in controls (12,25). It should be noted, however, that medial hypertrophy does not appear to occur in very small arteries (< 100 gm internal diameter) and arterioles, but rather appears confined to large and intermediate sized resistance arteries (i.e. 150–300 gm internal diameter) (8,19,26,40). Extensive medial hypertrophy occurs in large conduit vessels, such as the aorta (33). In these vessels, medial hypertrophy is thought to be an adaptive process to minimize changes in wall stress that occur as a consequence of increases in blood pressure (34).