Aqueous-Medium Selective Modification of Cysteine and Related Thiols with Tricyclic Oxygen-Heterocycles
Aqueous-Medium Selective Modification of Cysteine and Related Thiols with Tricyclic Oxygen-Heterocycles
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DOI：
10.1055/s-0036-1588497
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Eito Yoshioka;Yuya Goto;Ikko Minato;H. Miyabe
中科院分区：
文献类型：
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作者：
Eito Yoshioka;Yuya Goto;Ikko Minato;H. Miyabe
摘要通过使用L-半胱氨酸、同型半胱氨酸、巯甲丙脯酸和谷胱甘肽作为具有巯基的亲核试剂，证明了三环含氧杂环作为巯基选择性修饰朝向生物缀合的试剂的实用性。这些捕获反应在温和的水性反应条件下进行。
Abstract The utility of tricyclic oxygen-heterocycles as a reagent for the thiol-selective modification toward bioconjugation was demonstrated by the use of l-cysteine, homocysteine, captopril, and glutathione as a nucleophile having a thiol group. These trapping reactions proceeded under the mild and aqueous reaction conditions.