Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines
Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines
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DOI：
10.2196/11207
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发表时间：
2018-12-01
影响因子：
1.7
通讯作者：
Hudgens, Michael
中科院分区：
文献类型：
--
作者：
McCumber, Micah;Cain, Demetria;Hudgens, Michael
背景资料：青少年医学试验网络艾滋病毒/艾滋病干预（ATN）研究计划旨在击败美国青少年和年轻人中不断上升的艾滋病毒流行病。目的：本研究旨在优化交叉研究分析和标准化措施的比较方法：制定了指导方针，以协调跨ATN研究收集的措施。结果：确定了八个领域进行协调-人口统计学和社会经济特征，性行为和风险，物质使用和滥用，艾滋病毒阳性级联，艾滋病毒阴性级联，心理健康，社会支持和隔离，以及暴露前预防级联。以统一的方式在研究中收集选定的关键指标，有助于描述参与者人群的特征，进行研究之间的比较，并对多项研究的数据进行汇总分析。
Background: The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States.Objective: This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN.Methods: Guidelines were developed for harmonizing measures to be collected across ATN studies.Results: Eight domains were identified for harmonization-Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade.Conclusions: The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies.